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Relationship between Coffee Consumption and Osteoporosis Risk Determined by the ESR1 Polymorphism rs2982573

  • Original Research
  • Published:
The journal of nutrition, health & aging

Abstract

Background

The development of osteoporosis is partly explained by interactions between genetic and lifestyle or environmental factors.

Objectives

In the current study, we determined the relationship between coffee consumption and the risk of osteoporosis among individuals with ESR1 rs2982573 in Taiwan.

Design, Participants and Setting

In this population-based cross-sectional study, we used genetic, demographic, and lifestyle data from participants recruited in Taiwan Biobank (TWB) between 2016 and 2019. We used multiple logistic regression analyses to determine the relationship between osteoporosis and variant rs2982573 genotypes (TT, TC, and CC).

Main Outcome

The primary outcome was osteoporosis.

Results

Individuals with osteoporosis (n = 515) were older than those without the disease (mean age ±SE (year); 61.324±0.361 versus 53.068 ±0.130, p<0.001). There was no significant association between rs2982573 and osteoporosis (OR, 0.904; 95% CI, 0.706–1.157; p=0.422 for TC+CC when compared with the TT genotype). Coffee consumption was associated with a lower risk of osteoporosis (OR, 0.737; 95% CI, 0.592–0.918; p=0.006). The p-value for interaction between rs2982573 and coffee consumption was 0.0393. In our subgroup analyses, the adjusted ORs (95% CI) were 0.635 (0.410–0.985) in coffee drinking TC+CC individuals and 1.095 (0.809–1.482) in non-coffee drinking TC+CC individuals, respectively when compared with their TT genotype counterparts.

Conclusion

According to our study, participants in the TWB with the TC+CC genotype of ESR1 rs2982573 who consumed at least three cups of coffee per week were less likely to have osteoporosis.

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Funding

Funding: This study was supported by the Ministry of Science and Technology (MOST 109-2121-M-040-002, MOST 110-2121-M-040-002).

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Authors and Affiliations

  1. Department of Public Health and Institute of Public Health, Chung Shan Medical University, No. 110 Sec. 1 Jianguo N. Road, Taichung City, 40201, Taiwan

    C.-L. Wu, O. N. Nfor, W.-Y. Lu, D. Manli Tantoh & Yung-Po Liaw

  2. Department of Medical Imaging, Chung Shan Medical University Hospital, Taichung City, 40201, Taiwan

    D. Manli Tantoh & Yung-Po Liaw

Authors
  1. C.-L. Wu
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  2. O. N. Nfor
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  5. Yung-Po Liaw
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Contributions

Contributions: Conceptualization, Chi-Ling Wu, Oswald Ndi Nfor, Wen-Yu Lu, Disline Manli Tantoh and Yung-Po Liaw; Data curation, Wen-Yu Lu; Formal analysis, Oswald Ndi Nfor, Wen-Yu Lu and Yung-Po Liaw; Methodology, Chi-Ling Wu, Oswald Ndi Nfor, Disline Manli Tantoh and Yung-Po Liaw; Supervision, Yung-Po Liaw; Writing — original draft, Chi-Ling Wu; Writing — review & editing, Oswald Ndi Nfor, Wen-Yu Lu, Disline Manli Tantoh and Yung-Po Liaw.

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Correspondence to Yung-Po Liaw.

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Conflict of interests: The authors declare no conflict of interests.

Ethical standard: This paper is in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Wu, CL., Nfor, O.N., Lu, WY. et al. Relationship between Coffee Consumption and Osteoporosis Risk Determined by the ESR1 Polymorphism rs2982573. J Nutr Health Aging 26, 558–563 (2022). https://doi.org/10.1007/s12603-022-1796-6

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  • DOI: https://doi.org/10.1007/s12603-022-1796-6

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