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Association between Sleep Duration and Mild Cognitive Impairment at Different Levels of Metabolic Disease in Community-Dwelling Older Chinese Adults

  • Original Research
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The journal of nutrition, health & aging

Abstract

Objectives

The purpose of this study was to investigate the relationship between metabolic syndrome (MetS), sleep duration and mild cognitive impairment (MCI) in community-dwelling older Chinese adults.

Methods

The study comprised of 1367 community-dwelling Chinese participants (563 men; mean age: 71.0 years) recruited from Tianjin and Shanghai, China who were invited to participate in a comprehensive geriatric assessment. The International Diabetes Federation metabolic syndrome guidelines were used to define MetS. The Mini-Mental State Examination (MMSE) and the Instrumental Activities of Daily Living (IADL) scale were used for the initial classification of patients with MCI. We divided sleep duration into five groups (≤6 h, 6–8 h which was used as the reference, 8–9 h, 9–10 h, and >10 h). Nutritional status was assessed by Mini Nutrition Assessment Short Form.

Results

The overall incidence of metabolic syndrome was 46.7%, the overall incidence of mild cognitive impairment was 17.4%. In logistic regression analysis model, after adjusting for multiple confounding factors such as nutritional status and physical activity level, there was a significant positive association between long sleep duration (> 10h) and mild cognitive impairment in general population and metabolic syndrome population (p<0.05), but the association was not significant in non-metabolic syndrome group. In addition, in the long sleep duration group, the components of metabolic syndrome, elevated blood glucose were significantly associated with mild cognitive impairment (p<0.05).

Conclusions

Long sleep duration was significantly associated with increased risk of MCI in older adults with MetS, but not in those without MetS. The prevention of MCI may be more effective in the population of MetS with long sleep duration.

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Acknowledgements

All authors would like to thank Shao Guiyan of Chadian Public Health Center, Ren Xiaofang of Hangu Orphanage, and Gu Xiaoyue of Shanghai Chongming Health Service Center for providing venues and helping to organize their actions.

Funding

This work was supported by Shanghai Sailing Program (20YF1418200) and Wu Jieping medical foundation (320.6750.17073).

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Author notes

  1. Yinjiao Zhao contributed equally to this work and should be considered co-first author.

Authors and Affiliations

  1. Jiangwan Hospital of Shanghai Hongkou District, Shanghai University of Medicine and Health Science Affiliated First Rehabilitation Hospital, 1878 Sichuan North Road, Hongkou District, Shanghai, 200080, China

    P. Song, Yinjiao Zhao, H. Zhang, Fandi Xie & Qi Guo

  2. Department of Rehabilitation Medicine, Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital, 1500 Zhouyuan Road, Pudong New District, Shanghai, 201318, China

    X. Chen, P. Han & Qi Guo

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  1. P. Song
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Correspondence to Fandi Xie or Qi Guo.

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Song, P., Zhao, Y., Chen, X. et al. Association between Sleep Duration and Mild Cognitive Impairment at Different Levels of Metabolic Disease in Community-Dwelling Older Chinese Adults. J Nutr Health Aging 26, 139–146 (2022). https://doi.org/10.1007/s12603-022-1734-7

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