Skip to main content
SpringerLink
Log in

Correlation between Sarcopenia and Arteriosclerosis in Elderly Community Dwellers: A Multicenter Study

  • Published:
The journal of nutrition, health & aging

Abstract

Background

Evidence suggests that arteriosclerosis and sarcopenia (decreased muscle mass) share some of their many causes. However, after controlling for confounding factors, it is unclear whether the presence of arteriosclerosis correlates with sarcopenia.

Objectives

The aim of this paper is to explore whether sarcopenia is associated with arteriosclerosis.

Design

A multicenter cross-sectional community-based study. Materials and methods: A total of 2511 elderly subjects from six Chinese community health service centers in Anhui province were surveyed through an e-health promotion system to collect basic data and measurements of brachial-ankle pulse wave (baPWV), body composition, and handgrip strength (HGS). Pearson’s correlation and binary logistic regression analyses were performed to identify associations between sarcopenia and high baPWV.

Results

The prevalence rates of sarcopenia were 12.9% in men and 15.3% in women according to the 2019 standard of Asian Working Group for Sarcopenia. Among subjects with high baPWV, the proportion of sarcopenia was higher compared to those with normal baPWV (men: 17.7% vs. 3.7%; women: 20.4% vs. 4.9%, both p<0.001). Binary logistic regression analysis revealed that sarcopenia was associated with high baPWV (p<0.0001, odds ratio=1.619) after adjusting for confounding factors. HGS slightly and negatively correlated with baPWV (−0.19 in men and −0.18 in women).

Conclusions

The intertwined pathophysiological mechanisms shared by arteriosclerosis and sarcopenia are potential targets for future interventions to reduce morbimortality in subjects with both disorders. Upcoming prospective studies and clinical trials are expected to advance these findings.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1
Figure 2
Figure 3

Similar content being viewed by others

References

  1. Zeng Y, Hu X, Xie L, Han Z, Zuo Y, Yang M. The prevalence of sarcopenia in Chinese elderly nursing home residents: A comparison of 4 diagnostic criteria. J Am Med Dir Assoc 2018;19(8):690–695. doi:https://doi.org/10.1016/j.jamda.2018.04.015

    Article  Google Scholar 

  2. Chen LK, Woo J, Assantachai P, Auyeung TW, Chou MY, Iijima K, Jang HC, Kang L, Kim M, Kim S, Kojima T, Kuzuya M, Lee JSW, Lee SY, Lee WJ, Lee Y, Liang CK, Lim JY, Lim WS, Peng LN, Sugimoto K, Tanaka T, Won CW, Yamada M, Zhang T, Akishita M, Arai H. Asian Working Group for Sarcopenia: 2019 consensus update on sarcopenia diagnosis and treatment. J Am Med Dir Assoc 2020;21(3):300–307.e2. doi:https://doi.org/10.1016/j.jamda.2019.12.012

    Article  Google Scholar 

  3. Davies B, Garcia F, Ara I, Artalejo FR, Rodriguez-Manas L, Walter S. Relationship between sarcopenia and frailty in the toledo study of healthy aging: A population based cross-sectional study. J Am Med Dir Assoc 2018;19(4):282–286. doi:https://doi.org/10.1016/j.jamda.2017.09.014

    Article  CAS  Google Scholar 

  4. Yoshimura N, Muraki S, Oka H, Iidaka T, Kodama R, Kawaguchi H, Nakamura K, Tanaka S, Akune T. Is osteoporosis a predictor for future sarcopenia or vice versa? Four-year observations between the second and third ROAD study surveys. Osteoporos Int 2017;28(1):189–199. doi:https://doi.org/10.1007/s00198-016-3823-0

    Article  CAS  Google Scholar 

  5. Iwasaki M, Kimura Y, Ogawa H, Wada T, Sakamoto R, Ishimoto Y, Fujisawa M, Okumiya K, Ansai T, Miyazaki H, Matsubayashi K. The association between dentition status and sarcopenia in Japanese adults aged ≥75 years. J Oral Rehabil 2017;44(1):51–58. doi:https://doi.org/10.1111/joor.12460

    Article  CAS  Google Scholar 

  6. Tanishima S, Hagino H, Matsumoto H, Tanimura C, Nagashima H. Association between sarcopenia and low back pain in local residents prospective cohort study from the GAINA study. BMC Musculoskelet Disord 2017;18(1):452. doi:https://doi.org/10.1186/s12891-017-1807-7

    Article  Google Scholar 

  7. Wang T, Feng X, Zhou J, Gong H, Xia S, Wei Q, Hu X, Tao R, Li L, Qian F, Yu L. Type 2 diabetes mellitus is associated with increased risks of sarcopenia and pre-sarcopenia in Chinese elderly. Sci Rep 2016;6:38937. doi:https://doi.org/10.1038/srep38937

    Article  CAS  Google Scholar 

  8. Wang H, Hai S, Liu Y, Cao L, Liu Y, Liu P, Zhou J, Yang Y, Dong B. Association between depressive symptoms and sarcopenia in older Chinese community-dwelling individuals. Clin Interv Aging 2018;13:1605–1611. doi:https://doi.org/10.2147/CIA.S173146

    Article  Google Scholar 

  9. Hu X, Jiang J, Wang H, Zhang L, Dong B, Yang M. Association between sleep duration and sarcopenia among community-dwelling older adults: A cross-sectional study. Medicine (Baltimore) 2017;96(10):e6268. doi:https://doi.org/10.1097/MD.0000000000006268

    Google Scholar 

  10. Han P, Yu H, Ma Y, Kang L, Fu L, Jia L, Chen X, Yu X, Hou L, Wang L, Zhang W, Yin H, Niu K, Guo Q. The increased risk of sarcopenia in patients with cardiovascular risk factors in Suburb-Dwelling older Chinese using the AWGS definition. Sci Rep 2017;7(1):9592. doi:https://doi.org/10.1038/s41598-017-08488-8

    Article  Google Scholar 

  11. Hai S, Wang H, Cao L, Liu P, Zhou J, Yang Y, Dong B. Association between sarcopenia with lifestyle and family function among community-dwelling Chinese aged 60 years and older. BMC Geriatr 2017;17(1):187. doi:https://doi.org/10.1186/s12877-017-0587-

    Article  Google Scholar 

  12. Hai S, Cao L, Wang H, Zhou J, Liu P, Yang Y, Hao Q, Dong B. Association between sarcopenia and nutritional status and physical activity among community-dwelling Chinese adults aged 60 years and older. Geriatr Gerontol Int 2017;17(11):1959–1966. doi:https://doi.org/10.1111/ggi.13001

    Article  Google Scholar 

  13. Woo J, Leung J, Morley JE. Defining sarcopenia in terms of incident adverse outcomes. J Am Med Dir Assoc 2015;16(3):247–252. doi:https://doi.org/10.1016/j.jamda.2014.11.013

    Article  Google Scholar 

  14. Kuo YH, Wang TF, Liu LK, Lee WJ, Peng LN, Chen LK. Epidemiology of sarcopenia and factors associated with it among community-dwelling older adults in Taiwan. Am J Med Sci 2019;357(2):124–133. doi:https://doi.org/10.1016/j.amjms.2018.11.008

    Article  Google Scholar 

  15. Munakata M. Brachial-ankle pulse wave velocity in the measurement of arterial stiffness: Recent evidence and clinical applications. Curr Hypertens Rev 2014;10(1):49–57. doi:https://doi.org/10.2174/157340211001141111160957

    Article  Google Scholar 

  16. Yamashina A, Tomiyama H, Arai T, Hirose K, Koji Y, Hirayama Y, Yamamoto Y, Hori S. Brachial-ankle pulse wave velocity as a marker of atherosclerotic vascular damage and cardiovascular risk. Hypertens Res 2003;26(8):615–622. doi:https://doi.org/10.1291/hypres.26.615

    Article  Google Scholar 

  17. Yamashina A, Kario K, Kohara K, Sada M, Sugawara J, Suzuki H, et al. Guidelines for non-invasive vascular function test (JCS2013). http://www.j-circ.or.jp/guideline/pdf/JCS2013_yamashina_h.pdf

  18. Hu PP, Qu GJ, Luo SS. Research progress of sarcopenia and arteriosclerosis. Geriatr Health Care 2020;26(1):141–144. doi:https://doi.org/10.3969/j.issn.1008-8296.2020.01.037

    CAS  Google Scholar 

  19. Shuang T, Fu M, Yang G, Wu L, Wang R. The interaction of IGF-1/IGF-1R and hydrogen sulfide on the proliferation of mouse primary vascular smooth muscle cells. Biochem Pharmacol 2018;149:143–152. doi:https://doi.org/10.1016/j.bcp.2017.12.009

    Article  CAS  Google Scholar 

  20. Bahat G, Tufan A, Tufan F, Kilic C, Akpinar TS, Kose M, Erten N, Karan MA, Cruz-Jentoft AJ. Cut-off points to identify sarcopenia according to European Working Group on Sarcopenia in Older People (EWGSOP) definition. Clin Nutr 2016;35(6):1557–1563. doi:https://doi.org/10.1016/j.clnu.2016.02.002

    Article  Google Scholar 

  21. Yamanashi H, Kulkarni B, Edwards T, Kinra S, Koyamatsu J, Nagayoshi M, Shimizu Y, Maeda T, Cox SE. Association between atherosclerosis and handgrip strength in non-hypertensive populations in India and Japan. Geriatr Gerontol Int 2018;18(7):1071–1078. doi:https://doi.org/10.1111/ggi.13312

    Article  Google Scholar 

  22. van Dijk SC, Swart KM, Ham AC, Enneman AW, van Wijngaarden JP, Feskens EJ, Geleijnse JM, de Jongh RT, Blom HJ, Dhonukshe-Rutten RA, de Groot LC, van Schoor NM, Lips P, Uitterlinden AG, Mattace Raso FU, Smulders YM, van den Meiracker AH, van der Velde N. Physical fitness, activity and hand-grip strength are not associated with arterial stiffness in older individuals. J Nutr Health Aging 2015;19(7):779–784. doi:https://doi.org/10.1007/s12603-015-0519-7

    Article  CAS  Google Scholar 

  23. Abbatecola AM, Chiodini P, Gallo C, Lakatta E, Sutton-Tyrrell K, Tylavsky FA, Goodpaster B, de Rekeneire N, Schwartz AV, Paolisso G, Harris T, Health ABCs. Pulse wave velocity is associated with muscle mass decline: Health ABC study. Age (Dordr) 2012;34(2):469–478. doi:https://doi.org/10.1007/s11357-011-9238-0

    Article  Google Scholar 

  24. Hida T, Imagama S, Ando K, Kobayashi K, Muramoto A, Ito K, Ishikawa Y, Tsushima M, Nishida Y, Ishiguro N, Hasegawa Y. Sarcopenia and physical function are associated with inflammation and arteriosclerosis in community-dwelling people: The Yakumo study. Mod Rheumatol 2018;28(2):345–350. doi:https://doi.org/10.1080/14397595.2017.1349058

    Article  CAS  Google Scholar 

  25. Kalinkovich A, Livshits G. Sarcopenic obesity or obese sarcopenia: A cross talk between age-associated adipose tissue and skeletal muscle inflammation as a main mechanism of the pathogenesis. Ageing Res Rev 2017;35:200–221. doi:https://doi.org/10.1016/j.arr.2016.09.008

    Article  CAS  Google Scholar 

  26. Huang YQ, Li J, Chen JY, Zhou YL, Cai AP, Huang C, Feng YQ. The association of circulating miR-29b and interleukin-6 with subclinical atherosclerosis. Cell Physiol Biochem 2017;44(4):1537–1544. doi:https://doi.org/10.1159/000485649

    Article  CAS  Google Scholar 

  27. Stancel N, Chen CC, Ke LY, Chu CS, Lu J, Sawamura T, Chen CH. Interplay between CRP, atherogenic LDL, and LOX-1 and its potential role in the pathogenesis of atherosclerosis. Clin Chem 2016;62(2):320–327. doi:https://doi.org/10.1373/clinchem.2015.243923

    Article  CAS  Google Scholar 

  28. Lee YH, Jung KS, Kim SU, Yoon HJ, Yun YJ, Lee BW, Kang ES, Han KH, Lee HC, Cha BS. Sarcopaenia is associated with NAFLD independently of obesity and insulin resistance: Nationwide surveys (KNHANES 2008–2011). J Hepatol 2015;63(2):486–493. doi:https://doi.org/10.1016/j.jhep.2015.02.051

    Article  Google Scholar 

  29. Luevano-Contreras C, Garay-Sevilla ME, Wrobel K, Malacara JM, Wrobel K. Dietary advanced glycation end products restriction diminishes inflammation markers and oxidative stress in patients with type 2 diabetes mellitus. J Clin Biochem Nutr 2013;52(1):22–26. doi:https://doi.org/10.3164/jcbn.12-40

    Article  CAS  Google Scholar 

  30. Miyabe M, Ohashi K, Shibata R, Uemura Y, Ogura Y, Yuasa D, Kambara T, Kataoka Y, Yamamoto T, Matsuo K, Joki Y, Enomoto T, Hayakawa S, Hiramatsu-Ito M, Ito M, Van Den Hoff MJ, Walsh K, Murohara T, Ouchi N. Muscle-derived follistatin-like 1 functions to reduce neointimal formation after vascular injury. Cardiovasc Res 2014;103(1):111–120. doi:https://doi.org/10.1093/cvr/cvu105

    Article  CAS  Google Scholar 

Download references

Funding

Funding: This work was supported by the National Key R&D Program of China [grant number 2017YFB1002204] and Anhui Provincial Key Research and Development Project [grant number 18030801133].

Author information

Authors and Affiliations

  1. School of Nursing, Bengbu Medical College, 2600# Donghai Road, Bengbu, Anhui, 233030, China

    T. Sun & Hui Xie

  2. Anhui Province Key Laboratory of Medical Physics and Technology, Institute of Intelligent Machines, Hefei Institutes of Physical Sciences, Chinese Academy of Sciences, Hefei, Anhui, China

    Z. Ma, L. Gao & Y. Wang

Authors
  1. T. Sun
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Z. Ma
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. L. Gao
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Y. Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Hui Xie
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

Authors’ contributions: TS: data analysis, manuscript drafting. ZM: supervision, manuscript revision and editing. LG: manuscript editing. YW: data analysis. HX: data analysis, manuscript revision and editing.

Corresponding author

Correspondence to Hui Xie.

Ethics declarations

Ethics approval: All subjects provided written, informed consent for their data to be used in the study, and the study protocol was approved by the Ethics Committee of Bengbu Medical College (Anhui, China; no. 2018045). The Ethics Committee of Bengbu Medical College approved the study protocol (Anhui, China; no. 2018045).

Conflicts of interest: The authors of this paper have no competing interest.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Sun, T., Ma, Z., Gao, L. et al. Correlation between Sarcopenia and Arteriosclerosis in Elderly Community Dwellers: A Multicenter Study. J Nutr Health Aging 25, 692–697 (2021). https://doi.org/10.1007/s12603-021-1624-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12603-021-1624-4

Key words

Search

Navigation