Abstract
Background/Objectives
The physical phenotype of frailty, described by Fried et al., shows significant overlap with sarcopenia. EWGSOP2 recommends the SARC-F questionnaire to screen for sarcopenia. Considering common features between both conditions, we aimed to investigate whether the SARC-F questionnaire could also be a valid and reliable tool to screen or evaluate frailty.
Design
Retrospective, cross-sectional.
Setting
Istanbul University Istanbul Faculty of Medicine.
Participants
A total of 447 older adults (70.7% female, mean age: 74.5±6.6 years).
Measurements
Frailty was assessed by the modified Fried scale. SARC-F questionnaire was performed by all participants. We used a receiver operating characteristics curve to obtain SARC-F cut-off values to detect frailty, and calculated the area under the curve and 95% confidence interval.
Results
There were 93 (20.8%) older adults with frailty according to the modified Fried scale. SARC-F cut-off ≥1 had 91.4% sensitivity and 44.9% specificity. SARC-F cut-off ≥2 presented the best balance between sensitivity and specificity (sensitivity: 74.1% vs. specificity: 73.7%) to identify frailty (area under curve: 0.807; 95% confidence interval: 0.76–0.84, p<0.001). SARC-F ≥4 had high specificity of 92.6% with a sensitivity of 46.2%.
Conclusion
We suggest that SARC-F ≥1 point can be used to screen for frailty with high sensitivity, and SARC-F ≥4 can be used to diagnose frailty with high specificity. SARC-F may be used to evaluate frailty in usual geriatric practice.
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References
Fried LP, Tangen CM, Walston J, et al. Cardiovascular Health Study Collaborative Research Group Frailty in older adults: evidence for a phenotype. J Gerontol Med Sci. 2001;56A:M146–M156.
Clegg A, Young J, Iliffe S, Rikkert MO, Rockwood K. Frailty in elderly people. Lancet. 2013;381(9868):752–762.
Collard RM, Boter H, Schoevers RA, Oude Voshaar RC. Prevalence of frailty in community-dwelling older persons: a systematic review. J Am Geriatr Soc. 2012;60(8):1487–1492.
Morley JE, Vellas B, van Kan GA, et al. Frailty consensus: a call to action. J Am Med Dir Assoc. 2013;14(6):392–397.
Walston J, Hadley EC, Ferrucci L, et al. Research agenda for frailty in older adults: toward a better understanding of physiology and etiology: summary from the American Geriatrics Society /National Institute on Aging Research Conference on Frailty in Older Adults. J Am Geriatr Soc. 2006;54(6):991–1001.
Xue QL. The frailty syndrome: definition and natural history. Clin Geriatr Med. 2011;27(1):1–15.
Cruz-Jentoft AJ, Bahat G, Bauer J, et al. Sarcopenia: revised European consensus on definition and diagnosis [published correction appears in Age Ageing. 2019 Jul 1;48(4):601]. Age Ageing. 2019;48(1):16–31.
Bahat G, Yilmaz O, Kılıç C, Oren MM, Karan MA. Performance of SARC-F in Regard to Sarcopenia Definitions, Muscle Mass and Functional Measures. J Nutr HealthAging. 2018;22(8):898–903.
Fess EE (1992). Grip strength. In: Casanova JS (ed) Clinical assessment recommendations, American Society of Hand Therapists; 2nd edn. Chicago, pp 41–45.
Massy-Westropp NM, Gill TK, Taylor AW et al. Hand grip strength: age and gender stratified normative data in a population-based study. BMC Res Notes 2011; 14:127.
Cesari M, Leeuwenburgh C, Lauretani F, et al. Frailty syndrome and skeletal muscle: results from the Invecchiare in Chianti study. Am J Clin Nutr. 2006;83(5):1142–1148.
Bartali B, Frongillo EA, Bandinelli S, et al. Low nutrient intake is an essential component of frailty in older persons. J Gerontol A Biol Sci Med Sci. 2006; 61(6): 589–593.
Sheikh JI, Yesavage JA. Geriatric Depression Scale (GDS): recent evidence and development of a shorter version. Clin Gerontol. 1986;5(1/2):165–173.
Folstein MF, Folstein SE, McHugh PR. “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975;12(3):189–198.
Rubenstein LZ, Harker JO, Salvà A, Guigoz Y, Vellas B. Screening for undernutrition in geriatric practice: developing the short-form mini-nutritional assessment (MNA-SF). J Gerontol A Biol Sci Med Sci. 2001;56(6):M366–M372.
Katz S, Ford AB, Moskowitz RW, Jackson BA, Jaffe MW. Studies of Illness in the Aged: The Index of ADL: A Standardized Measure of Biological and Psychosocial Function. JAMA. 1963;185(12):914–919.
Lawton MP, Brody EM. Assessment of older people: self-maintaining and instrumental activities of daily living. Gerontologjst. 1969;9(3):179–186.
Wang J, Geng L. Effects of socioeconomic status on physical and psychological health: lifestyle as a mediator. Int. J. Environ. Res. Public Health. 2019; 16:281.
Boyd CM, Xue QL, Simpson CF, Guralnik JM, Fried LP. Frailty, hospitalization, and progression of disability in a cohort of disabled older women. Am J Med. 2005;118:1225–1231.
Jung HW, Jang IY, Lee CK, et al. Usual gait speed is associated with frailty status, institutionalization, and mortality in community-dwelling rural older adults: a longitudinal analysis of the Aging Study of Pyeongchang Rural Area. Clin Interv Aging. 2018;13:1079–1089. Published 2018 Jun 6.
Morley JE. Frailty and sarcopenia in elderly. Wien Klin Wochenschr. 2016;128(Suppl 7):439–445.
Vanleerberghe P, De Witte N, Claes C, Schalock RL, Verté D. The quality of life of older people aging in place: a literature review. Qual Life Res. 2017;26(11):2899–2907.
Yeung SSY, Reijnierse EM, Pham VK, et al. Sarcopenia and its association with falls and fractures in older adults: A systematic review and meta-analysis. J Cachexia Sarcopenia Muscle. 2019;10(3):485–500.
Cheng MH, Chang SF. Frailty as a Risk Factor for Falls Among Community Dwelling People: Evidence From a Meta-Analysis. J Nurs Scholarsh. 2017;49(5):529–536.
Huo YR, Suriyaarachchi P, Gomez F et al. Comprehensive nutritional status in sarcoosteoporotic olderfallers. J Nutr Health Aging 2015;19:474–480.
Morley JE. Anemia in the nursing homes: a complex issue. J Am Med Dir Assoc. 2012; 13:191–4.
Dominguez LJ, Bevilacqua M, Dibella G, Barbagallo M. Diagnosing and managing thyroid disease in the nursing home. J Am Med Dir Assoc. 2008;9(1):9–17.
Smith L, Thomas EL, Bell JD, Hamer M. The association between objectively measured sitting and standing with body composition: A pilot study using MRI. BMJ Open. 2014;4:e005476.
Chevalier S, Gougeon R, Nayar K, Morais JA. Frailty amplifies the effects of aging on protein metabolism: role of protein intake. Am J Clin Nutr. 2003;78(3):422–429.
Parra-Rodríguez L, Szlejf C, García-González AI, Malmstrom TK, Cruz-Arenas E, Rosas-Carrasco O. Cross-Cultural Adaptation and Validation of the Spanish-Language Version of the SARC-F to Assess Sarcopenia in Mexican Community-Dwelling Older Adults. J Am Med Dir Assoc. 2016;17(12):1142–1146.
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Conflict of Interest: There are no other relationships/conditions/circumstances that present a potential conflict of interest.
Ethical standards: The study was conducted according to guidelines in the Declaration of Helsinki. The study was approved from the local ethic committee.
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Statement of Authorship: Mehmet Akif Karan: Supervision, Reviewing and Editing. Cihan Kilic: Data curation. Gulistan Bahat: Conceptualization, Methodology, Software, Writing- Original draft preparation, Validation, Writing- Reviewing and Editing, Supervision. Serdar Ozkok: Writing- Reviewing and Editing.
Sponsor’s role: None.
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Bahat, G., Ozkok, S., Kilic, C. et al. SARC-F Questionnaire Detects Frailty in Older Adults. J Nutr Health Aging 25, 448–453 (2021). https://doi.org/10.1007/s12603-020-1543-9
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DOI: https://doi.org/10.1007/s12603-020-1543-9