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Predictive Value of Serum Creatinine/Cystatin C in Acute Ischemic Stroke Patients under Nutritional Intervention

  • Published:
The journal of nutrition, health & aging

Abstract

Background and Purpose

As a very common risk of adverse outcomes of the ischemic stroke patients, sarcopenia is associated with infectious complications and higher mortality. The goal of this retrospective study is to explore the predictive value of serum Cr/CysC ratio in acute ischemic stroke patients receiving nutritional intervention.

Methods

We reviewed adult patients with AIS from December 2019 to February 2020. Patients with acute kidney injury were excluded and all patients received nutritional intervention during a 3-month follow-up period. We collected baseline data at admission including creatinine and cystatin C. The primary poor outcome was major disability (modified Rankin Scale score ≥ 4) at 3 months after AIS.

Results

A total of 217 patients with AIS were identified for this study. Serum Cr/CysC ratio was significantly correlated with NIHSS at discharge, 1-month modified Rankin Scale score, and 3-month modified Rankin Scale score. During 3 months, 34 (15.70%) patients had a poor outcome after AIS and 11 (5.10%) patients died within 30 days. In multivariable logistic regression analyses, serum Cr/CysC ratio at admission was independently associated with 3-month poor outcomes (OR: 0.953, 95% CI: 0.921–0.986, p =.006) and 30-day mortality (OR: 0.953, 95% CI: 0.921–0.986, p =.006).

Conclusion

As a blood biochemical indexes reflecting the muscle mass and aiding in risk stratification, Cr/CysC ratio at admission could be used as a predictor of 30-day mortality and long-term poor prognosis in AIS patients.

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Availability of data and materials: Original data of the present study are available from the corresponding author upon reasonable request.

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Acknowledgments

We would like to thank Prof. Wanli Dong for valuable comments on this manuscript.

Funding

Funding: This work was supported by the grants from National Key R&D Program of China (2017YFC0110304).

Author information

Author notes

  1. Wei Liu, Xiangyi Zhu and Xin Tan contributed equally.

Authors and Affiliations

  1. Departments of Neurology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215000, China

    W. Liu, X. Zhu, X. Tan, Y. Wang, S. Diao, S. Huang, X. Zhang, Yi Yang & Jianqiang Ni

  2. Department of Neurology, Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, Jiangsu, China

    W. Liu

  3. School of public health, Fujian Medical University, Fuzhou, Fujian, China

    L. Yang

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  1. W. Liu
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Contributions

Authors’ contributions: WL, YY, and JN designed the study. WL, XZ, XT, YW, SD, SH, XZ and YY evaluated the subjects and collected the data. LY and YY analyzed the data. WL wrote the initial draft, with YY and JN participating in revising the manuscript.

Corresponding authors

Correspondence to Yi Yang or Jianqiang Ni.

Ethics declarations

Consent for publication: Not applicable.

Competing interests: On behalf of all authors, the corresponding author states that there is no conflict of interest.

Ethics approval and consent to participate: This study involving human participants were reviewed and approved by the Institutional Review Board of The First Affiliated Hospital of Soochow University. The experiment comply with the current laws of the country in which they were performed. All patients gave informed consent.

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Liu, W., Zhu, X., Tan, X. et al. Predictive Value of Serum Creatinine/Cystatin C in Acute Ischemic Stroke Patients under Nutritional Intervention. J Nutr Health Aging 25, 335–339 (2021). https://doi.org/10.1007/s12603-020-1495-0

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  • DOI: https://doi.org/10.1007/s12603-020-1495-0

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