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Establishment of a Risk Prediction Model for Mild Cognitive Impairment Among Elderly Chinese

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The journal of nutrition, health & aging

Abstract

Background

Mild cognitive impairment (MCI) is a transitional stage of cognitive function between normal aging and dementia. Substantial variations in the prevalence of MCI in different countries have been studied including China. In this study, we established a prediction system to assess the risk of MCI among the elderly in China.

Methods

The Rothman-Keller model was conducted on the basis of the risk factors of MCI obtained by the combined results of a meta-analysis. The accuracy of the model was verified using actual population data.

Results

A total of 1826 subjects as a verification set were enrolled in this study in February 2019. There were statistically significant differences in the combined results of 10 risk factors including hypertension, diabetes, educational level, hyperlipidemia, smoking, physical exercise, living alone, stroke, drinking and heart disease (P<0.05). The area under the curve (AUC) of the actual data and the predictive results of this model was 0.859 (95%CI: 0.812–0.906, P<0.05), the sensitivity was 86.6% and the specificity was 76.5%.

Conclusions

This model performs an effective prediction that may be applied to the primary prevention for patients with MCI, helping to reduce the risk of MCI.

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Acknowledgement

This work was supported by Fund Project of Shanghai Science and Technology Commission (No. 16411972900).

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Authors and Affiliations

  1. Department of Neurology, Shanghai General Hospital of Nanjing Medical University, Shanghai, 200080, P.R. China

    B. Wang & Xiaoping Wang

  2. Department of Neurology, Shanghai First People’s Hospital Baoshan Branch, Shanghai, 200940, P.R. China

    B. Wang, T. Shen, L. Mao, L. Xie & Q.-L. Fang

  3. Department of Neurology, Tongren Hospital Shanghai Jiao Tong University School of Medicine, Shanghai, 200336, P.R. China

    Xiaoping Wang

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  1. B. Wang
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Correspondence to Xiaoping Wang.

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This research was approved by the Institutional Review Board of Shanghai First People’s Hospital Baoshan Branch (approval number: 2016Y02).

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All authors declare that they have no conflict of interest.

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Wang, B., Shen, T., Mao, L. et al. Establishment of a Risk Prediction Model for Mild Cognitive Impairment Among Elderly Chinese. J Nutr Health Aging 24, 255–261 (2020). https://doi.org/10.1007/s12603-020-1335-2

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  • DOI: https://doi.org/10.1007/s12603-020-1335-2

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