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Creatinine to Cystatin C Ratio as a Marker of Bone Property in Older Adults: The J-Shipp Study

  • Published:
The journal of nutrition, health & aging

Abstract

Objectives

To clarify whether serum creatinine to cystatin C ratio (CCR), a marker of muscle mass and muscle function may be used as a simple marker of bone property.

Design

A cross-sectional analysis.

Setting

A general population-based observation study. Participants: 1,606 middle-aged to elderly (≥50 years, mean age: 66.9 ± 7.5 years old) men (n = 642) and post-menopausal women (n = 964).

Measurement

Speed of sound (SOS) at the calcaneal bone was used as a surrogate marker of bone mineral density. The cross-sectional area of the muscle at the mid-thigh was measured using computed tomography.

Results

There was significant linear correlation between the quartiles of CCR and SOS (Q1: 1,495 ± 25, Q2: 1,499 ± 24, Q3: 1,507 ± 26, Q4: 1,511 ± 25 m/sec; P < 0.001) even in a sex-separated analysis. This association was independent of major covariates (Q1: β = −0.126, P < 0.001; Q2: β = −0.096, P = 0.001; Q3: β = −0.022; P = 0.412, Q4: reference) and the mid-thigh muscle mass, while creatinine alone or eGFR did not show clear association with SOS.

Conclusion

The CCR may be used as a simple marker of bone property independently of muscle mass in a general population with preserved renal function.

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Acknowledgment

The authors are deeply indebted to the staff members of the J-SHIPP study. We also thank the editors of Enago for the English language review.

Author information

Authors and Affiliations

  1. Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Shogoinkawara-cho, Sakyo-ku, Kyoto, 606-8507, Japan

    Yasuharu Tabara

  2. Department of Regional Resource Management, Faculty of Collaborative Regional Innovation, Ehime University, Matsuyama, Japan

    K. Kohara

  3. Department of Neurology and Geriatric Medicine, Ehime University Graduate School of Medicine, Toon, Japan

    Yasuharu Tabara, Y. Okada & Y. Ohyagi

  4. Department of Anti-aging Medicine, Ehime University Graduate School of Medicine, Toon, Japan

    M. Igase

Authors
  1. Yasuharu Tabara
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  2. K. Kohara
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  3. Y. Okada
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  4. Y. Ohyagi
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  5. M. Igase
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Corresponding author

Correspondence to Yasuharu Tabara.

Ethics declarations

All study procedures were approved by the ethics committee of Ehime University Graduate School of Medicine. Written informed consent was obtained from all participants.

Additional information

Conflict of interest

The Department of Anti-aging Medicine at Ehime University is funded by endowments from Nitta Gelatin Incorporated to the Ehime University.

Financial support

This research was supported by the Grant-in-Aid for Scientific Research (20018020, 19659163, 20390185, 23659382, 24390084, 23659352, 25293141, 26670313, 17H04123, 18K18450, 17H04123) from the Ministry of Education, Culture, Sports, Science and Technology of Japan, research grant from the Japan Atherosclerosis Prevention Found, National Cardiovascular Research Grants, and Research Promotion Award from the Ehime University.

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Tabara, Y., Kohara, K., Okada, Y. et al. Creatinine to Cystatin C Ratio as a Marker of Bone Property in Older Adults: The J-Shipp Study. J Nutr Health Aging 24, 277–281 (2020). https://doi.org/10.1007/s12603-020-1315-6

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  • DOI: https://doi.org/10.1007/s12603-020-1315-6

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