The journal of nutrition, health & aging

, Volume 23, Issue 4, pp 348–353 | Cite as

The Effect of Branched Chain Amino Acids-Enriched Nutritional Supplements on Activities of Daily Living and Muscle Mass in Inpatients with Gait Impairments: A Randomized Controlled Trial

  • Misa MoriwakiEmail author
  • H. Wakabayashi
  • K. Sakata
  • K. Domen



To investigate the effects of continuous intervention with branched chain amino acids-enriched nutritional supplements from the acute phase to convalescent rehabilitation wards in inpatients with gait impairments.


Open-label, randomized, parallel-group comparison study (UMIN Clinical Trials Registry ID: UMIN000018640).


Acute care and convalescent rehabilitation wards


We studied 80 patients undergoing stand/gait training.


Participants in the intervention group (RJ group) received nutritional supplements (jelly foods comprising 2500 mg BCAA and 20 IU vitamin D) twice a day until hospital discharge.


The primary outcome was the motor components of the Functional Independence Measure (FIM-m), and the secondary outcome was skeletal muscle mass index.


Analyses were conducted on 55 patients who were able to perform stand/gait training continuously from the acute until the recovery phases. FIM-m was significantly elevated in the RJ group and the control group, but no difference was noted between the two groups. Only the RJ group showed a significant increase in skeletal muscle mass index, and the amount of variation was significantly different between the two groups (the control group decreased an average of 2.2% and the RJ group increased an average of 4.3%; P = 0.014). A significant decrease in body weight was found only in the control group (P = 0.084).


Nutritional interventions using branched chain amino acids (BCAA)-enriched nutritional supplements demonstrated no significant difference in activities of daily living; however, an increase in skeletal muscle mass was noted. Skeletal muscle mass and body weight differed significantly between the two groups, and BCAA-enriched nutritional supplements intake in acute and convalescent rehabilitation wards may be effective for the prevention of malnutrition and sarcopenia.

Key words

Rehabilitation gait impairments sarcopenia nutrition nutritional supplement 


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Copyright information

© Serdi and Springer-Verlag International SAS, part of Springer Nature 2019

Authors and Affiliations

  • Misa Moriwaki
    • 1
    Email author
  • H. Wakabayashi
    • 2
  • K. Sakata
    • 1
  • K. Domen
    • 3
  1. 1.Department of Rehabilitation MedicineMidorigaoka HospitalTakatsuki, OsakaJapan
  2. 2.Department of Rehabilitation MedicineYokohama City University Medical CenterYokohama City, KanagawaJapan
  3. 3.Department of Rehabilitation MedicineHyogo College of MedicineNishinomiya City, HyogoJapan

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