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How Dietary Patterns are Related to Inflammaging and Mortality in Community-Dwelling Older Chinese Adults in Hong Kong — A Prospective Analysis

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The journal of nutrition, health & aging

Abstract

Introduction

Studies examining dietary patterns and inflammageing in relation to mortality are limited.

Objective

We examined the influence of various dietary patterns on all-cause and cardiovascular disease (CVD) mortality, taking into account demographics, lifestyle factors, and serum inflammatory markers.

Methods

We conducted multivariate Cox regression analyses using data from a cohort of communitydwelling older Chinese adults (1,406 men, 1,396 women) in Hong Kong. Baseline interviewer administered questionnaires covered dietary intake estimation and dietary pattern generation from the food frequency questionnaire, demographic and lifestyle factors, cognitive function and depressive symptoms. Serum high-sensitivity C-reactive protein (hsCRP) and 25-hydroxyvitamin D (25OHD) were measured. All-cause and CVD mortality data at 14-year follow up were retrieved from an official database.

Results

In men, higher hsCRP level was associated with lower Diet Quality Index-International (DQI-I) score, Mediterranean-DASH Intervention for Neurodegenerative Delay Diet (MIND) score, Okinawan diet score, “vegetables-fruits” pattern score and “snacks-drinks-milk” pattern score. Higher serum 25OHD level was associated with higher Mediterranean Diet Score (MDS) but lower “snacks-drinks-milk” pattern score. None of the dietary pattern scores was associated with all-cause or CVD mortality after adjusting for all covariates. In women, hsCRP level and serum 25OHD level were not associated with any dietary patterns. Higher DQI-I score (HR=0.77 (95% CIs: 0.59, 0.99) highest vs. lowest tertile, p-trend=0.038) and Okinawan diet score (HR=0.78 (95% CIs: 0.61, 1.00) highest vs lowest tertile, p-trend=0.046) was associated with a lower risk of all-cause mortality, whereas higher MIND score (HR=0.63 (95% CI: 0.36, 1.09) highest vs. lowest tertile, p-trend=0.045) was associated with a reduced risk of CVD morality in the multivariate adjusted model.

Conclusion

Higher DQI-I score and Okinawan diet score were associated with a lower risk of all-cause mortality, and higher adherence to the MIND diet was related to a reduced risk of CVD mortality in community-dwelling Chinese older women.

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Authors and Affiliations

  1. Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong

    Ruth S. M. Chan, B. W. M. Yu, J. S. W. Lee, T. W. Auyeung, T. Kwok & J. Woo

  2. The Chinese University of Hong Kong Jockey Club Centre for Osteoporosis Care and Control, Shatin, Hong Kong

    B. W. M. Yu & J. Leung

  3. The Chinese University of Hong Kong Jockey Club Institute of Ageing, Shatin, Hong Kong

    J. Woo

  4. Department of Medicine and Therapeutics, Prince of Wales Hospital, Shatin, N.T., Hong Kong

    Ruth S. M. Chan

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  1. Ruth S. M. Chan
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Correspondence to Ruth S. M. Chan.

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Chan, R.S.M., Yu, B.W.M., Leung, J. et al. How Dietary Patterns are Related to Inflammaging and Mortality in Community-Dwelling Older Chinese Adults in Hong Kong — A Prospective Analysis. J Nutr Health Aging 23, 181–194 (2019). https://doi.org/10.1007/s12603-018-1143-0

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