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Serum long-chain omega-3 polyunsaturated fatty acids and future blood pressure in an ageing population

  • Published:
The journal of nutrition, health & aging

Abstract

Objectives

To investigate the associations of serum long-chain omega-3 polyunsaturated fatty acids (PUFA) and hair mercury with future blood pressure in an ageing population.

Design

Prospective study with baseline measurements in 1998–2001 and follow-up measurements in 2005–2008. The linear relationships (β) of baseline serum fatty acids and hair mercury with future systolic and diastolic blood pressure and pulse pressure were analyzed with multiple linear regression models, using log-transformed values.

Participants

181 men and 200 women aged 53–73 y from the Kuopio Ischemic Heart Disease Risk Factor Study (KIHD) population in Eastern Finland, who were free of cardiovascular disease, diabetes or hypertension at baseline.

Measurements

Total serum esterified and nonesterified fatty acids and pubic hair mercury were used as markers for exposure. Anthropometric and other lifestyle and health-related data were collected.

Results

The mean serum concentrations were 1.67% (SD 0.92) for eicosapentaenoic acid (EPA), 0.79% (SD 0.16) for docosapentaenoic acid (DPA) and 2.78 (SD 0.92) for docosahexaenoic acid (DHA), of all serum fatty acids. The mean hair mercury concentration was 1.5 μg/g (SD 1.6). We did not find statistically significant associations between the baseline serum long-chain omega-3 PUFA concentrations or hair mercury content and future blood pressure. Hair mercury did not modify the associations with the long-chain omega-3 PUFAs, either.

Conclusions

Higher serum long-chain omega-3 PUFA concentration, a biomarker of fish or fish oil consumption, may not have an impact on future blood pressure in an ageing population.

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References

  1. Pauletto P, Puato M, Caroli MG, Casiglia E, Munhambo AE, Cazzolato G, Bittolo Bon G, Angeli MT, Galli C, Pessina AC. Blood pressure and atherogenic lipoprotein profiles of fish-diet and vegetarian villagers in Tanzania: the Lugalawa study. Lancet 1996;348:784–788.

    Article  CAS  PubMed  Google Scholar 

  2. Dallongeville J, Yarnell J, Ducimetiere P, Arveiler D, Ferrieres J, Montaye M, Luc G, Evans A, Bingham A, Hass B, Ruidavets JB, Amouyel P. Fish consumption is associated with lower heart rates. Circulation 2003;108:820–825.

    Article  PubMed  Google Scholar 

  3. Mozaffarian D, Gottdiener JS, Siscovick DS. Intake of tuna or other broiled or baked fish versus fried fish and cardiac structure, function, and hemodynamics. Am J Cardiol 2006;97:216–222.

    Article  PubMed  Google Scholar 

  4. Ueshima H, Stamler J, Elliott P, Chan Q, Brown IJ, Carnethon MR, Daviglus ML, He K, Moag-Stahlberg A, Rodriguez BL, Steffen LM, Van Horn L, Yarnell J, Zhou B, INTERMAP Research Group. Food omega-3 fatty acid intake of individuals (total, linolenic acid, long-chain) and their blood pressure: INTERMAP study. Hypertension 2007;50:313–319.

    Article  CAS  PubMed  Google Scholar 

  5. Virtanen JK, Nyantika AN, Kauhanen J, Voutilainen S, Tuomainen TP. Serum long-chain n-3 polyunsaturated fatty acids, methylmercury and blood pressure in an older population. Hypertens Res 2012;35:1000–1004.

    Article  CAS  PubMed  Google Scholar 

  6. Miller PE, Van Elswyk M, Alexander DD. Long-chain omega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid and blood pressure: a meta-analysis of randomized controlled trials. Am J Hypertens 2014;27:885–896.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  7. Xun P, Hou N, Daviglus M, Liu K, Morris JS, Shikany JM, Sidney S, Jacobs DR, He K. Fish oil, selenium and mercury in relation to incidence of hypertension: a 20-year follow-up study. J Intern Med 2011;270:175–186.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  8. Roman HA, Walsh TL, Coull BA, Dewailly E, Guallar E, Hattis D, Marien K, Schwartz J, Stern AH, Virtanen JK, Rice G. Evaluation of the cardiovascular effects of methylmercury exposures: Current evidence supports development of a dose-response function for regulatory benefits analysis. Environ Health Perspect 2011;119:607–614.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  9. Mozaffarian D, Shi P, Morris JS, Grandjean P, Siscovick DS, Spiegelman D, Willett WC, Rimm EB, Curhan GC, Forman JP. Mercury exposure and risk of hypertension in US men and women in 2 prospective cohorts. Hypertension 2012;60:645–652.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  10. Virtanen JK, Voutilainen S, Rissanen TH, Mursu J, Tuomainen TP, Korhonen MJ, Valkonen VP, Seppanen K, Laukkanen JA, Salonen JT. Mercury, fish oils, and risk of acute coronary events and cardiovascular disease, coronary heart disease, and all-cause mortality in men in eastern Finland. Arterioscler Thromb Vasc Biol 2005;25:228–233.

    CAS  PubMed  Google Scholar 

  11. Virtanen JK, Laukkanen JA, Mursu J, Voutilainen S, Tuomainen TP. Serum long-chain n-3 polyunsaturated fatty acids, mercury, and risk of sudden cardiac death in men: a prospective population-based study. PLoS One 2012;7:e41046.

    Article  Google Scholar 

  12. Salonen JT. Is there a continuing need for longitudinal epidemiologic research? The Kuopio Ischaemic Heart Disease Risk Factor Study. Ann Clin Res 1988;20:46–50.

    CAS  PubMed  Google Scholar 

  13. Laaksonen DE, Lakka TA, Lakka HM, Nyyssonen K, Rissanen T, Niskanen LK, Salonen JT. Serum fatty acid composition predicts development of impaired fasting glycaemia and diabetes in middle-aged men. Diabet Med 2002;19:456–464.

    Article  CAS  PubMed  Google Scholar 

  14. Salonen JT, Nyyssonen K, Korpela H, Tuomilehto J, Seppanen R, Salonen R. High stored iron levels are associated with excess risk of myocardial infarction in eastern Finnish men. Circulation 1992;86:803–811.

    Article  CAS  PubMed  Google Scholar 

  15. Lakka TA, Venäläinen JM, Rauramaa R, Salonen R, Tuomilehto J, Salonen JT. Relation of leisure-time physical activity and cardiorespiratory fitness to the risk of acute myocardial infarction. N Engl J Med 1994;330:1549–1554.

    Article  CAS  PubMed  Google Scholar 

  16. Voutilainen S, Rissanen TH, Virtanen J, Lakka TA, Salonen JT. Low dietary folate intake is associated with an excess incidence of acute coronary events: The Kuopio Ischemic Heart Disease Risk Factor Study. Circulation 2001;103:2674–2680.

    Article  CAS  PubMed  Google Scholar 

  17. Salonen JT, Seppanen K, Nyyssonen K, Korpela H, Kauhanen J, Kantola M, Tuomilehto J, Esterbauer H, Tatzber F, Salonen R. Intake of mercury from fish, lipid peroxidation, and the risk of myocardial infarction and coronary, cardiovascular, and any death in eastern Finnish men. Circulation 1995;91:645–655.

    Article  CAS  PubMed  Google Scholar 

  18. Kaikkonen JE, Jula A, Mikkila V, Viikari JS, Moilanen T, Nikkari T, Kahonen M, Lehtimaki T, Raitakari OT. Childhood serum cholesterol ester fatty acids are associated with blood pressure 27 y later in the Cardiovascular Risk in Young Finns Study. Am J Clin Nutr 2012;95:1422–1431.

    Article  CAS  PubMed  Google Scholar 

  19. Pedersen EB, Jorgensen ME, Pedersen MB, Siggaard C, Sorensen TB, Mulvad G, Hansen JC, Asmund G, Skjoldborg H. Relationship between mercury in blood and 24-h ambulatory blood pressure in Greenlanders and Danes. Am J Hypertens 2005;18:612–618.

    Article  CAS  PubMed  Google Scholar 

  20. Fillion M, Mergler D, Sousa Passos CJ, Larribe F, Lemire M, Guimaraes JR. A preliminary study of mercury exposure and blood pressure in the Brazilian Amazon. Environ Health 2006;5:29.

    Article  PubMed Central  PubMed  Google Scholar 

  21. Valera B, Dewailly E, Poirier P. Environmental mercury exposure and blood pressure among Nunavik Inuit adults. Hypertension 2009;54:981–986.

    Article  CAS  PubMed  Google Scholar 

  22. Choi AL, Weihe P, Budtz-Jorgensen E, Jorgensen PJ, Salonen JT, Tuomainen TP, Murata K, Nielsen HP, Petersen MS, Askham J, Grandjean P. Methylmercury exposure and adverse cardiovascular effects in Faroese whaling men. Environ Health Perspect 2009;117:367–372.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  23. Vupputuri S, Longnecker MP, Daniels JL, Guo X, Sandler DP. Blood mercury level and blood pressure among US women: results from the National Health and Nutrition Examination Survey 1999–2000. Environ Res 2005;97:195–200.

    Article  CAS  PubMed  Google Scholar 

  24. Nikkari T, Luukkainen P, Pietinen P, Puska P. Fatty acid composition of serum lipid fractions in relation to gender and quality of dietary fat. Ann Med 1995;27:491–498.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio Campus, PO Box 1627, 70211, Kuopio, Finland

    A. N. Nyantika, T. -P. Tuomainen, J. Kauhanen, S. Voutilainen & Jyrki K. Virtanen

  2. Department of Public Health, University of Eastern Africa, Baraton, Kenya

    A. N. Nyantika

Authors
  1. A. N. Nyantika
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  2. T. -P. Tuomainen
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  3. J. Kauhanen
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  4. S. Voutilainen
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  5. Jyrki K. Virtanen
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Corresponding author

Correspondence to Jyrki K. Virtanen.

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Nyantika, A.N., Tuomainen, T.P., Kauhanen, J. et al. Serum long-chain omega-3 polyunsaturated fatty acids and future blood pressure in an ageing population. J Nutr Health Aging 19, 498–503 (2015). https://doi.org/10.1007/s12603-015-0463-6

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  • DOI: https://doi.org/10.1007/s12603-015-0463-6

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