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Nutrition and the biology of human ageing: Molecular mechanisms underlying ageing

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The journal of nutrition, health & aging

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References

  1. Bernardes de JB, Vera E, Schneeberger K, Tejera AM, Ayuso E, Bosch F, Blasco MA. Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer. EMBO Mol Med. 2012 Aug;4:691–704.

    Article  Google Scholar 

  2. Greer EL, Maures TJ, Hauswirth AG, Green EM, Leeman DS, Maro GS, Han S, Banko MR, Gozani O, Brunet A. Members of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegans. Nature. 2010 Jul 15;466:383–387.

    Article  CAS  Google Scholar 

  3. Greer EL, Maures TJ, Ucar D, Hauswirth AG, Mancini E, Lim JP, Benayoun BA, Shi Y, Brunet A. Transgenerational epigenetic inheritance of longevity in Caenorhabditis elegans. Nature. 2011 Nov 17;479:365–371.

    Article  PubMed  CAS  Google Scholar 

  4. Vicencio JM, Galluzzi L, Tajeddine N, Ortiz C, Criollo A, Tasdemir E, Morselli E, Ben YA, Maiuri MC, et al. Senescence, apoptosis or autophagy? When a damaged cell must decide its path—a mini-review. Gerontology. 2008;54:92–99.

    Article  PubMed  Google Scholar 

  5. Eisenberg T, Knauer H, Schauer A, Buttner S, Ruckenstuhl C, Carmona-Gutierrez D, Ring J, Schroeder S, Magnes C, et al. Induction of autophagy by spermidine promotes longevity. Nat Cell Biol. 2009 Nov;11:1305–1314.

    Article  PubMed  CAS  Google Scholar 

  6. Jia K, Levine B. Autophagy is required for dietary restriction-mediated life span extension in C. elegans. Autophagy. 2007 Nov;3:597–599.

    PubMed  Google Scholar 

  7. Mattison JA, Roth GS, Beasley TM, Tilmont EM, Handy AM, Herbert RL, Longo DL, Allison DB, Young JE, et al. Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study. Nature. 2012 Aug 29.

    Google Scholar 

  8. Colman RJ, Anderson RM, Johnson SC, Kastman EK, Kosmatka KJ, Beasley TM, Allison DB, Cruzen C, Simmons HA, et al. Caloric restriction delays disease onset and mortality in rhesus monkeys. Science. 2009 Jul 10;325:201–204.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland

    S. M. Gasser

  2. Nestlé Research Center, Lausanne, Switzerland

    J. Le Coutre

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  1. S. M. Gasser
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  2. J. Le Coutre
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Correspondence to J. Le Coutre.

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Gasser, S.M., Le Coutre, J. Nutrition and the biology of human ageing: Molecular mechanisms underlying ageing. J Nutr Health Aging 17, 710–711 (2013). https://doi.org/10.1007/s12603-013-0373-4

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  • DOI: https://doi.org/10.1007/s12603-013-0373-4

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