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Mortality as an adverse outcome of sarcopenia

Abstract

Sarcopenia has an important impact in elderly. Recently the European Working Group on Sarcopenia in Older People (EWGSOP) defined sarcopenia as the loss of muscle mass plus low muscle strength or low physical performance. Lack of clinical sounding outcomes (ie external validity), is one of the flaws of this algorithm. The aim of our study was to determine the association of sarcopenia and mortality in a group of Mexican elderly. A total of 345 elderly were recruited in Mexico City, and followed up for three years. The EWGSOP algorithm was integrated by: gait speed, grip strength and calf circumference. Other covariates were assessed in order to test the independent association of sarcopenia with mortality. Of the 345 subjects, 53.3% were women; with a mean age of 78.5 (SD 7) years. During the three year follow-up a total of 43 (12.4%) subjects died. Age, cognition, ADL, IADL, health self-perception, ischemic heart disease and sarcopenia were associated in the bivariate analysis with survival. Negative predictive value for sarcopenia regarding mortality was of 90%. Kaplan-Meier curves along with their respective log-rank test were significant for sarcopenia. The components of the final Cox-regression multivariate model were age, ischemic heart disease, ADL and sarcopenia. Adjusted HR for age was 3.24 (CI 95% 1.55–6.78 p 0.002), IHD 5.07 (CI 95% 1.89–13.59 p 0.001), health self-perception 5.07 (CI 95% 1.9–13.6 p 0.001), ADL 0.75 (CI 95% 0.56–0.99 p 0.048) and sarcopenia 2.39 (CI 95% 1.05–5.43 p 0.037).

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References

  1. Baumgartner RN, Koehler KM, Gallagher D, Romero L, Heymsfield SB, et al (1998) Epidemiology of sarcopenia among the elderly in New Mexico. Am J Epidemiol, 1998. 147: 755–763.

    PubMed  Article  CAS  Google Scholar 

  2. Thompson DD (2007) Aging and sarcopenia. J Musculoskelet Neuronal Interact. 7: 344–345.

    PubMed  CAS  Google Scholar 

  3. Roubenoff R (2001) Origins and clinical relevance of sarcopenia. Can J Appl Physiol 26: 78–89.

    PubMed  Article  CAS  Google Scholar 

  4. Lauretani F, Russo CR, Bandinelli S, Bartali B, Cavazzini C, et al (2003) Ageassociated changes in skeletal muscles and their effect on mobility: an operational diagnosis of sarcopenia. J Appl Physiol 95: 1851–1860.

    PubMed  Google Scholar 

  5. Janssen I (2010) Evolution of sarcopenia research. Appl Physiol Nutr Metab 35: 707–712. doi: 10.1139/H10-067

    PubMed  Article  Google Scholar 

  6. Abellan van Kan G (2009) Epidemiology and consequences of sarcopenia. J Nutr Health Aging 13: 708–712.

    PubMed  Article  CAS  Google Scholar 

  7. Arango-Lopera VE, Arroyo, P, Gutiérrez-Robledo LM, Pérez-Zepeda MU (2012) Prevalence of sarcopenia in Mexico City. Eur Geriatr Med. doi:10.1016/j.eurger.2011.12.001.

    Google Scholar 

  8. Fielding RA, Vellas B, Evans WJ, Bhasin S, et al (2011) Sarcopenia: an undiagnosed condition in older adults. Current consensus definition: prevalence, etiology, and consequences. International working group on sarcopenia. J Am Med Dir Assoc 12: 249–256. doi: 10.1016/j.jamda.2011.01.003

    PubMed  Article  Google Scholar 

  9. Cruz-Jentoft AJ, Baeyens JP, Bauer JM, Boirie Y, Cederholm T, Landi F, et al (2010) Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People. Age Ageing 39(4): p. 412–423. doi: 10.1093/ageing/afq034

    PubMed  Article  Google Scholar 

  10. Patel HP, Syddall HE, Martin HJ, Stewart CE, Cooper C, Sayer AA, et al (2010) Hertfordshire sarcopenia study: design and methods. BMC Geriatr 10: 43. doi: 10.1186/1471-2318-10-43

    PubMed  Article  Google Scholar 

  11. Villareal DT, Banks M, Siener C, Sinacore DR, Klein S (2004) Physical frailty and body composition in obese elderly men and women. Obes Res 12: 913–920. doi: 10.1038/oby.2004.111

    PubMed  Article  Google Scholar 

  12. Inouye SK, Studenski S, Tinetti ME, Kuchel GA (2007) Geriatric syndromes: clinical, research, and policy implications of a core geriatric concept. J Am Geriatr Soc 55: 780–791. doi: 10.1111/j.1532-5415.2007.01156.x

    PubMed  Article  Google Scholar 

  13. Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J, Seeman T, et al (2001) Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci 56: p. M146–156.

    PubMed  Article  CAS  Google Scholar 

  14. Bauer JM, Sieber CC (2008) Sarcopenia and frailty: a clinician’s controversial point of view. Exp Gerontol 43: 674–678. doi: 10.1016/j.exger.2008.03.007

    PubMed  Article  CAS  Google Scholar 

  15. Mexico City Government, Padrón de Beneficiarios del Programa de Pensión Alimentaria del Distrito Federal, 2011, Gobierno del Distrito Federal: http://www.sideso.df.gob.mx/index.php?id=399. Accessed 20 July 2011.

  16. Rolland Y, Lauwers-Cances V, Cournot M, Nourhashémi F, Reynish W, et al (2003) Sarcopenia, calf circumference, and physical function of elderly women: a crosssectional study. J Am Geriatr Soc 51: 1120–1124.

    PubMed  Article  Google Scholar 

  17. Franco-Marina F, García-González JJ, Wagner-Echeagaray F, Gallo J, García-Peña C, et al (2010) The Mini-mental State Examination revisited: ceiling and floor effects after score adjustment for educational level in an aging Mexican population. Int Psychogeriatr 22: 72–81. doi: 10.1017/S1041610209990822

    PubMed  Article  Google Scholar 

  18. Rueda-Jaimes GE, Lopez-Camargo MT, Campo-Arias A (2009) [Validacion de una version abreviada de la Escala para Depresion del Centro de Estudios Epidemiologicos (CES-D) en adultos colombianos] Rev Colomb Psiquiatr 38: 734–745.

    Google Scholar 

  19. Katz S (1983) Assessing self-maintenance: activities of daily living, mobility, and instrumental activities of daily living. J Am Geriatr Soc 3: 721–727.

    Google Scholar 

  20. Lawton MP, Brody EM (1969) Assessment of older people: self-maintaining and instrumental activities of daily living. Gerontologist 9: 179–186.

    PubMed  Article  CAS  Google Scholar 

  21. Podsiadlo D, Richardson S (1991) The timed “Up & Go”: a test of basic functional mobility for frail elderly persons. J Am Geriatr Soc 39: 142–148.

    PubMed  CAS  Google Scholar 

  22. Guigoz Y, Vellas B, Garry PJ (1996) Assessing the nutritional status of the elderly: The Mini Nutritional Assessment as part of the geriatric evaluation. Nutr Rev 54: S59–65.

    PubMed  Article  CAS  Google Scholar 

  23. Ensrud KE, Ewing SK, Taylor BC, Fink HA, Cawthon PM (2008) Comparison of 2 frailty indexes for prediction of falls, disability, fractures, and death in older women. Arch Intern Med 168: 382–389.

    PubMed  Article  Google Scholar 

  24. Bunout D, de la Maza MP, Barrera B, Leiva L, Hirsch S (2011) Association between sarcopenia and mortality in healthy older people. Australas J Ageing 30: 89–92. doi: 10.1111/j.1741-6612.2010.00448.x

    PubMed  Article  Google Scholar 

  25. Landi F, Liperoti R, Fusco D, Mastropaolo S, Quattrociocchi D, et al (2011) Sarcopenia and Mortality among Older Nursing Home Residents. J Am Med Dir Assoc. doi: 10.1016/j.jamda.2011.07.004

    Google Scholar 

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Correspondence to Luis Miguel Gutiérrez-Robledo.

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Arango-Lopera, V.E., Arroyo, P., Gutiérrez-Robledo, L.M. et al. Mortality as an adverse outcome of sarcopenia. J Nutr Health Aging 17, 259–262 (2013). https://doi.org/10.1007/s12603-012-0434-0

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  • DOI: https://doi.org/10.1007/s12603-012-0434-0

Key words

  • Sarcopenia
  • survival
  • nutrition in elderly