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A flexible electrochemical sensor for paracetamol based on porous honeycomb-like NiCo-MOF nanosheets

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The overdose of 4-aminophenol (AP) threatens human health, and the determination of AP is crucial. Here, we report a flexible electrochemical sensor for highly sensitive and precise determination of AP. The ultrathin honeycomb-like NiCo-MOF nanosheets were in situ grown on free-standing flexible carbon cloth (CC) electrode. The porous structure among nanosheets and rich porosity of NiCo-MOF shorten the transport path of electrolyte ions and reactants, ensuring fast electron transport. The large specific surface area (62.14 m2·g−1) provides much active site, and NiCo-MOF exhibits high catalytic activity toward AP. The proposed NiCo-MOF/CC-based sensor showed a wide linear range from 5.0 to 400 μmol·L−1 with a detection limit of 1.0 μmol·L−1. The selectivity, reproducibility and stability were also verified to be satisfactory. In addition, it can detect AP in real pills. The developed flexible sensor endows its promising potential in fabrication of wearable devices.

Graphical abstract

摘要

4-氨基酚(AP)的过量使用严重威胁人体健康，对其的测定至关重要。在此，我们报道了一种用于高灵敏和精确测定AP的柔性电化学传感器。在自支撑柔性碳布(CC)电极上原位生长了超薄蜂窝状NiCo-MOF纳米片。NiCo-MOF丰富的孔隙度和纳米片之间的多孔结构缩短了电解质离子和反应物的传输路径，保证了快速的电子传递。NiCo-MOF的大比表面积(62.14 m2∙g−1)提供了大量的活性位点，对AP具有较高的催化活性。该传感器可检测较宽浓度范围的AP（5.0 ~ 400 μmol·L-1），检出限为1.0 μmol·L-1。该方法的选择性、重复性和稳定性结果均获得了满意的结果。此外，它还可以检测真正的药片中的AP。研制的柔性传感器在可穿戴设备制造中具有广阔的应用前景。

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Acknowledgements

This work was financially supported by the National Natural Science Foundation of China (Nos. 51802118, 52272212 and 11904131), the Natural Science Foundation of Shandong Province (Nos. ZR2022JQ20 and ZR2021YQ04), the Taishan Scholar Project of Shandong Province (No. tsqn202211168) and the Key Laboratory of Optic-electric Sensing and Analytical Chemistry for Life Science, MOE (No. M2022-7).

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  1. Xiu-Li Liu and Wei-Jia Guo have contributed equally to this work.

Authors and Affiliations

  1. Institute for Advanced Interdisciplinary Research, School of Chemistry and Chemical Engineering, University of Jinan, Jinan, 250022, China

    Xiu-Li Liu, Jia-Wei Guo, Ya-Wen Wang, Ai-Zhu Wang, Xin Yu & Long-Hua Ding

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  1. Xiu-Li Liu
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Liu, XL., Guo, JW., Wang, YW. et al. A flexible electrochemical sensor for paracetamol based on porous honeycomb-like NiCo-MOF nanosheets. Rare Met. 42, 3311–3317 (2023). https://doi.org/10.1007/s12598-023-02349-2

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