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Numerical study of photonic crystal fiber-based optical biosensor for detection of cervical cancer

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Abstract

The present study has been performed with the purpose of designing a highly sensitive biosensor for cervical cancer cell detection. The structure of the proposed design for biosensor includes a hollow core, four-quarter circular-type airholes spread through the cladding region, and Zeonex (R.I.-1.53) as background fiber material. Further, guiding properties of the proposed waveguide have been studied. The suggested photonic crystal fiber structure has been operated in the THz frequency regime. COMSOL Multiphysics 5.6a software based on finite element method and MATLAB 17b software have been used to examine various guiding properties of the sensor. Various performance parameters such as effective refractive index 1.3414, effective area 8.4733 × 10−9 µm2, nonlinearity 9.9468W−1 km−1, propagation constant 2.5703 × 10−26, relative sensitivity 78.68%, and confinement loss 5.1406 × 10−26 cm−1 have been evaluated for cervical cancer cells. The simplified design reduces fabrication complexity and makes it cost-effective. It enhances the optical sensing capabilities of the proposed sensor model. The proposed design will add new opportunities in the field of bio photonics. Moreover, it leads to better applications in medical field for detecting and diagnosing cervical cancer cells disease.

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Acknowledgements

The authors are very grateful to the research articles which was helpful in our research work. One of the authors (Dharini Srivastava) is thankful to MMMUT, Gorakhpur.

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Authors and Affiliations

  1. Photonics and Photovoltaic Research Lab, Department of Physics and Material Science, Madan Mohan Malaviya University of Technology, Gorakhpur, 273010, India

    Dharini Srivastava, Sapana Yadav, Adarsh Chandra Mishra & D. K. Dwivedi

  2. Institute of Advanced Materials, IAAM, Gammalkilsvägen, 59053, Ulrika, Sweden

    Sachin Singh

  3. Department of Electronics and Communication Engineering, Madan Mohan Malaviya University of Technology, Gorakhpur, 273010, India

    Pooja Lohia

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  1. Dharini Srivastava
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Srivastava, D., Yadav, S., Mishra, A.C. et al. Numerical study of photonic crystal fiber-based optical biosensor for detection of cervical cancer. J Opt 53, 1155–1162 (2024). https://doi.org/10.1007/s12596-023-01254-2

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