Skip to main content
Log in

The Dynamics of the Flow of Blood in the Human Circulatory System

  • Original Research
  • Published:
Differential Equations and Dynamical Systems Aims and scope Submit manuscript

Abstract

This paper introduces a realistic framework for the blood flow dynamics in the human circulatory system, wherein blood changes its characteristics while flowing through different arteries, from elastic to muscular to rigid. We believe that this approach is significantly different from most of the literature of the related work, wherein the blood flow characteristics remain the same throughout its flow in an artery. Another interesting idea in this work is the introduction of a nonlinear relationship between flux and the pressure gradient that has been found appropriate for the blood flow in coronary arteries. Further, this work suggests to the researchers that if one considers the varying material properties of the blood that flows through the different constituent pipes (blood vessels), one would be able to gain adequate understanding on the vital issues in treating the problems related to blood circulation, such as blood clots, stenotic growth and bypass grafting surgeries.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  1. Mazumdar, J.N.: Bio-Fluid Mechanics. World Scientific Publishing, Singapore (2004)

    Google Scholar 

  2. Quarteroni, A., Formaggia, L.: Mathematical modelling and numerical simulation of the cardiovascular system. Handb. Num. Anal. Elsevier 12, 3–127 (2004)

    Article  MathSciNet  Google Scholar 

  3. Oh, Y.S.: Arterial stiffness and hypertension. Clin. Hypertens. 24, 13–18 (2018)

    Article  Google Scholar 

  4. Wagenseil, J.E., Mecham, R.P.: Elastin in large artery stiffness and hypertension. J. Cardiovasc. Transl. Res. 5(3), 264–273 (2012)

    Article  Google Scholar 

  5. Weisbrod, R.M., et al.: Arterial stiffening precedes systolic hypertension in diet-induced obesity. Hypertension 62(6), 1105–1110 (2013)

    Article  Google Scholar 

  6. Vaudo, G., Schillaci, G., Evangelista, F., Pasqualini, L., Verdecchia, P., Mannarino, E.: Arterial wall thickening at different sites and its association with left ventricular hypertrophy in newly diagnosed essential hypertension. Am. J. Hypertens. 13(4), 324–333 (2000)

    Article  Google Scholar 

  7. Chen, Z., Ichetovkin, M., Kurtz, M., et al.: Cholesterol in human atherosclerotic plaque is a marker for underlying disease state and plaque vulnerability. Lipids Health Dis. 9, 1–8 (2010)

    Article  Google Scholar 

  8. Ku, D.N.: Blood flow in arteries. Annu. Rev. Fluid Mech. 29, 399–434 (1997)

    Article  MathSciNet  Google Scholar 

  9. Gerrard, J.H., Taylor, L.A.: Mathematical model representing blood flow in arteries. Med. Biol. Eng. Comput 15, 611–617 (1977)

    Article  Google Scholar 

  10. Ibanez, R., Shokrian, M., Nam, J.H., Kelley, D.H.: Simple analytic model for peristaltic flow and mixing. Phys. Rev. Fluids 6(10), 103101 (2021)

    Article  Google Scholar 

  11. Chakravarty, S., Mandal, P.K.: Mathematical modelling of blood flow through an overlapping arterial stenosis. Math. Comput. Model. 19(1), 59–70 (1994)

    Article  MATH  Google Scholar 

  12. Watanabe, S.M., Blanco, P.J., Feijóo, R.A.: Mathematical model of blood flow in an anatomically detailed arterial network of the arm. ESAIM M2AN 47(4), 961–985 (2013)

    Article  MathSciNet  MATH  Google Scholar 

  13. Zhang, X., Caruso, C., Lam, W.A., Graham, M.D.: Flow-induced segregation and dynamics of red blood cells in sickle cell disease. Phys. Rev. Fluids 5(5), 053101 (2020)

    Article  Google Scholar 

  14. Canic, S., Tambaca, J., Guidoboni, G., Mikelic, A., Hartley, C.J., Rosenstrauch, D.: Modeling viscoelastic behaviour of arterial walls and their interaction with pulsatile blood flow. SIAM J. Appl. Math. 67(1), 164–193 (2006)

    Article  MathSciNet  MATH  Google Scholar 

  15. Quarteroni, A.: Modeling the cardiovascular system—a mathematical adventure: Part II. SIAM News 34 (2001)

  16. Hoef, T., Meuwissen, M., Piek, J.J.: Interventional cardiology: Fractional flow reserve and beyond. Heart (British Cardiac Society) 99, 1705 (2013)

    Google Scholar 

  17. Mohammad, A., Hussain, S.K., Puniyani, R.R.: Relationship between power-law coefficients and major blood constituents affecting the whole blood viscosity. J. Biosci. 24(3), 329–337 (1999)

    Article  Google Scholar 

  18. Roach, M.R., Burton, A.C.: The reason for the shape of the distensibility curves of arteries. Can. J. Biochem. Physiol. 35(8), 681–690 (1957)

    Article  Google Scholar 

  19. Rubinow, S.I., Keller, J.B.: Flow of a viscous fluid through an elastic tube with applications to blood flow. J. Theor. Biol. 35(2), 299–313 (1972)

    Article  Google Scholar 

Download references

Acknowledgements

The authors wish to thank the anonymous reviewers for their constructive remarks, which have facilitated this revision. The research of the first author (VSHR) is supported by the Foundation for Scientific Research and Technological Innovation (FSRTI)- A Constituent Division of Sri Vadrevu Seshagiri Rao Memorial Charitable Trust, Hyderabad-500102, India.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to T. S. L. Radhika.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

S.I.: In memory of Prof. Herbert I. Freedman.

Rights and permissions

Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Rao, V.S.H., Radhika, T.S.L. The Dynamics of the Flow of Blood in the Human Circulatory System. Differ Equ Dyn Syst 31, 673–685 (2023). https://doi.org/10.1007/s12591-022-00617-8

Download citation

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12591-022-00617-8

Keywords

Navigation