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Comparison of PET imaging with a 68Ga-labelled PSMA ligand versus 18F-choline PET/CT for the diagnosis of Prostate Cancer & Radioprotection for involved personnel

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Abstract

To compare the radiation dose delivered by Positron Emission Tomography (PET) due to Gallium-68 (68Ga) and Fluorine-18(18F) performed for patients with prostate cancer. The greatest importance is to understand how the extremely strong sources in use can be managed effectively and doses to persons and unwanted doses to patients can be minimized. Thus, Radiation safety measurements are necessary to achieve the lowest exposure with reasonable cost and effort. We prospectively analyzed studies from 70 patients who underwent PET-CT using 68Ga or 18F for diagnosis of prostate cancer between January 2017 and December 2017 at the American University of Beirut Medical Center. The dose rates were measured during the uptake period at patient body surface (abdomen) and at 1 m distance; these two points were measured after one hour of radionuclide uptake with background of 0.018 μSv. Then, the equivalent dose is calculated. Patients were selected consecutively until 70 cases were selected for each type of radionuclide. Data on 140 patients are presented. The maximum dose given to 68Ga PSMA (prostate-specific membrane antigen) patients was 5.80 mCi while doses to 18F-Choline patients reached 8.87 mCi. Cronbach’s Alpha values for the correlation between the masses and the dose rates was 0.530.Thus there is a small positive relationship between the body masses and the dose rates. This relationship is not statistically significant. Furthermore, the equivalent dose for both radionuclides was constant whatever the mass of the patient is. There is no effect of the body mass with respect to the dose rate, and equivalent dose due to both radionuclides 68Ga and 18F, which coincides with the principles of radiation protection. This leads to the suggestion that PET/CT equivalent doses with 68Ga-labelled PSMA ligand or 18F-Choline are similar and safe in the diagnosis of prostate cancer. However, 68Ga PSMA coincides more with radiation protection principles since the maximum equivalent dose due to 68Ga after 1 h at 1 m was 17.71 μSv while the maximum equivalent dose due to 18F after 1 h at 1 m was 39.51 μSv.

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Abbreviations

PET:

Positron Emission Tomography

CT:

Computed Tomography

PC:

Prostate Cancer

PSMA:

Prostate-Specific Membrane Antigen

Inj:

Injection

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Authors and Affiliations

  1. Department of Physics, Beirut Arab University, P. O. Box 11-5020, Beirut, 1107-2809, Lebanon

    Zeinab Khansa & Mahmoud Korek

  2. Department of Diagnostic Radiology, American University of Beirut Medical Center, P.O. Box: 11-0236, Riad El Solh, Beirut, 1107-2020, Lebanon

    Mohamad B. Haidar & Nemer Neaimeh

Authors
  1. Zeinab Khansa
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  2. Mohamad B. Haidar
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  3. Nemer Neaimeh
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  4. Mahmoud Korek
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Contributions

Zeinab Khansa: contributed data collection and manuscript preparation.

Mohamad B. Haidar: contributed to data collection, study design and manuscript editing.

Nemer Neaimeh: contributed to data collection.

Mahmoud Korek: contributed to study design.

All authors read and approved the final manuscript.

Corresponding author

Correspondence to Mohamad B. Haidar.

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Khansa, Z., Haidar, M.B., Neaimeh, N. et al. Comparison of PET imaging with a 68Ga-labelled PSMA ligand versus 18F-choline PET/CT for the diagnosis of Prostate Cancer & Radioprotection for involved personnel. Health Technol. 9, 607–613 (2019). https://doi.org/10.1007/s12553-018-00281-5

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  • DOI: https://doi.org/10.1007/s12553-018-00281-5

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