Abstract
Nanomaterials are one of the most promising classes of advanced materials with fine-tuned biological activities. This is evidenced by the presence of redox activity of a number of nanoparticles aimed at inhibiting free radicals and/or mimicking the functions of enzymes. At the same time, it is impossible to study the expression of these biological properties without the use of well-standardized, representative techniques that provide availability, high precision, sensitivity, and selectivity of the measured characteristics. A method that satisfies these requirements is chemiluminescence analysis, which is widely used both in clinical analysis and to characterize the antioxidant activity of substances of natural or synthetic origin. Recently, a trend of using chemiluminescence analysis to study the biological activity of nanomaterials has appeared as a suitable alternative to spectroscopic and electrochemical techniques. This review briefly describes the examples of successful applications of chemiluminescence methods to study radical-binding and enzyme-like activities of nanomaterials. We discuss the data about the effect of the used reagents (radical-generating systems, chemiluminescence activators) and experimental conditions on the obtained values characterizing the nanomaterials activity.
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Data availability
The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.
Abbreviations
- CL:
-
Chemiluminescence
- CLA:
-
Chemiluminescence analysis
- ATP:
-
Adenosine triphosphate
- ROS:
-
Reactive oxygen species
- ARA:
-
Antiradical activity
- ABAP:
-
2,2′-azo-bis 2-amidinpropane
- SOD:
-
Superoxide dismutase
- TRAP:
-
Total radical-trapping antioxidant potential
References
Alexeev A, Proskurnina EV, Vladimirov YA (2012) Determination of antioxidants by sensitized chemiluminescence using 2,2′-azo-bis(2-amidinopropane). Mosc Univ Chem Bull 67:127–132. https://doi.org/10.3103/S0027131412030029
Bedlovicova Z, Strapa I, Balaz M, Salayova AA (2020) Brief overview on antioxidant activity determination of silver nanoparticles. Molecules 25:3191–3215. https://doi.org/10.3390/molecules25143191
Bondar VS, Shimomura O, Gitelson JI (2012) Luminescence of higher mushrooms. J Sib Fed Univ Biol 4:331–351. https://doi.org/10.17516/1997-1389-0127
Das S, Dowding JM, Klump KE, McGinnis JF, Self W, Seal S (2013) Cerium oxide nanoparticles: applications and prospects in nanomedicine. Nanomedicine 8:1483–1508. https://doi.org/10.2217/nnm.13.133
Deshpande S, Patil S, Kuchibhatla S, Seal S (2005) Size dependency variation in lattice parameter and valency states in nanocrystalline cerium oxide. Appl Phys Lett 87:133113–133117. https://doi.org/10.1063/1.2061873
Dodeigne C, Thunus L, Lejeune R (2000) Chemiluminescence as diagnostic tool, A review. Talanta 51:415–439. https://doi.org/10.1016/s0039-9140(99)00294-5
Fleiss A, Sarkisyan KS (2019) A brief review of bioluminescent systems. Curr Genet 65:877–882. https://doi.org/10.1007/s00294-019-00951-5
Guo S, Deng Q, Xiao J, Xie B, Sun Z (2007) Evaluation of antioxidant activity and preventing DNA damage effect of pomegranate extracts by chemiluminescence method. J Agric Food Chem 55:3134–3140. https://doi.org/10.1021/jf063443g
Han L, Shi J, Liu A (2017) Novel biotemplated MnO2 1D nanozyme with controllable peroxidase-like activity and unique catalytic mechanism and its application for glucose sensing. Sens Actuators B Chem 252:919–926. https://doi.org/10.1016/j.snb.2017.06.096
Jagiello K, Chomicz B, Avramopoulos A, Gajewicz A, Mikolajczyk A, Bonifassi P, Papadopoulos M, Leszczynski J, Puzyn T (2017) Size-dependent electronic properties of nanomaterials: how this novel class of nanodescriptors supposed to be calculated? Struct Chem 28:635–643. https://doi.org/10.1007/s11224-016-0838-2
Kanan SM, Malkawi A (2021) Recent advances in nanocomposite luminescent metal-organic framework sensors for detecting metal ions. Comments Inorg Chem 41:1–66. https://doi.org/10.1080/02603594.2020.1805319
Kumar H, Bhardwaj K, Nepovimova E, Kuča K, Dhanjal DS, Bhardwaj S, Bhatia SK, Verma R, Kumar D (2020) Antioxidant functionalized nanoparticles: a combat against oxidative stress. Nanomaterials (Basel) 10:1334–1360. https://doi.org/10.3390/nano10071334
Lesnichaya M, Shendrik R, Titov E, Sukhov B (2020) Synthesis and comparative assessment of antiradical activity, toxicity, and biodistribution of κ-carrageenan-capped selenium nanoparticles of different size: in vivo and in vitro study. IET Nanobiotechnol 14:519–526. https://doi.org/10.1049/iet-nbt.2020.0023
Li Z, Yang X, Yang Y, Tan Y, He Y, Liu M, Liu X, Yuan Q (2018) Peroxidase-mimicking nanozyme with enhanced activity and high stability based on metal-support interactions. Chemistry 24:409–415. https://doi.org/10.1002/chem.201703833
Li CW, Li LL, Chen S, Zhang JX, Lu WL (2020) Antioxidant Nanotherapies for the Treatment of Inflammatory Diseases. Front Bioeng Biotechnol 18:200–207. https://doi.org/10.3389/fbioe.2020.00200
Lv C, Di W, Liu Z, Zheng K, Qin W (2014) Luminescent CePO4:Tb colloids for H2O2 and glucose sensing. Analyst 139:4547–4555. https://doi.org/10.1039/c4an00952e
Maji SK, Mandal AK, Nguyen KT, Borah P, Zhao Y (2015) Cancer cell detection and therapeutics using peroxidase-active nanohybrid of gold nanoparticle-loaded mesoporous silica-coated graphene. ACS Appl Mater Interfaces 7:9807–9816. https://doi.org/10.1021/acsami.5b01758
Mikheev IV, Sozarukova MM, Izmailov DY, Kareev IE, Proskurnina EV, Proskurnin MA (2021) Antioxidant potential of aqueous dispersions of fullerenes C60, C70, and Gd@C82. Int J Mol Sci 22:5838. https://doi.org/10.3390/ijms22115838
Naumova EV, Vladimirov YA, Beloussov LV, Tuchin VV, Volodyaev IV (2021) Methods of studying ultraweak photon emission from biological objects: i. history, types and properties, fundamental and application significance. Biophysics 66:764–778. https://doi.org/10.1134/S0006350921050158
Nelson BC, Johnson ME, Walker ML, Riley KR, Sims CM (2016) Antioxidant cerium oxide nanoparticles in biology and medicine. Antioxidants 5:15. https://doi.org/10.3390/antiox5020015
Oleiwi AH, Neamah SR, Atshan AM (2021) The phenomenon of bioluminescence in insects. Sci Arch 2:62–64. https://doi.org/10.47587/SA.2021.2110
Romodin LA (2021) Chemiluminescence detection in the study of free-radical reactions. Part 1. Acta Nat 13:90–100. https://doi.org/10.32607/actanaturae.10912
Romodin LA (2022) Chemiluminescence detection in the study of free-radical reactions. Part 2. Luminescent additives that increase the chemiluminescence quantum yield. Acta Nat 14:31–39. https://doi.org/10.32607/actanaturae.11427
Sim S, Wong NK (2021) Nanotechnology and its use in imaging and drug delivery (Review). Biomed Rep 14:1–9. https://doi.org/10.3892/br.2021.1418
Soares S, Sousa J, Pais A, Vitorino C (2018) Nanomedicine: principles, properties, and regulatory issues. Front Chem 6:360–366. https://doi.org/10.3389/fchem.2018.00360
Sozarukova MM, Proskurnina EV, Baranchikov AE, Ivanov VK (2020a) CeO2 nanoparticles as free radical regulators in biological systems. Nanosyst: Phys Chem Math 11:324–332. https://doi.org/10.17586/2220-8054-2020-11-3-324-332
Sozarukova MM, Shestakova MA, Teplonogova MA, Izmailov DY, Proskurnina EV, Ivanov VK (2020b) Quantification of free radical scavenging properties and sod-like activity of cerium dioxide nanoparticles in biochemical models. Russ J Inorg Chem 65:597–605. https://doi.org/10.1134/S0036023620040208
Sozarukova MM, Proskurnina EV, Ivanov VK (2021a) Prooxidant potential of CeO2 nanoparticles towards hydrogen peroxide. Nanosyst: Phys Chem Math 12:283–290. https://doi.org/10.17586/2220-8054-2021-12-3-283-290
Sozarukova MM, Proskurnina EV, Popov AL, Kalinkin AL, Ivanov VK (2021b) New facets of nanozyme activity of ceria: lipo- and phospholipoperoxidase-like behaviour of CeO2 nanoparticles. RSC Adv 11:35351–35360. https://doi.org/10.1039/d1ra06730c
Tsunekawa S, Ishikawa K, Li Z, Kawazoe Y, Kasuya A (2000) Origin of anomalous lattice expansion in oxide nanoparticles. Phys Rev Lett 85:3440–3443. https://doi.org/10.1103/PhysRevLett.85.3440
Vaiserman A, Koliada A, Zayachkivska A, Lushchak O (2020) Nanodelivery of natural antioxidants: an anti-aging perspective. Front Bioeng Biotechnol 7:447–454. https://doi.org/10.3389/fbioe.2019.00447
Valgimigli L, Baschieri A, Amorati R (2018) Antioxidant activity of nanomaterials. J Mater Chem B 6:2036–2051. https://doi.org/10.1039/C8TB00107C
Valiadi M, Iglesias-Rodriguez D (2013) Understanding bioluminescence in dinoflagellates-how far have we come? Microorganisms 1:3–25. https://doi.org/10.3390/microorganisms1010003
Vinothkumar G, Lalitha AI, Suresh Babu K (2019) Cerium phosphate-cerium oxide heterogeneous composite nanozymes with enhanced peroxidase-like biomimetic activity for glucose and hydrogen peroxide sensing. Inorg Chem 58:349–358. https://doi.org/10.1021/acs.inorgchem.8b02423
Vladimirov YA, Proskurnina EV (2009) Free radicals and cell chemiluminescence. Biochemistry 74:1545–1566. https://doi.org/10.1134/s0006297909130082
Vladimirov YA, Atanayev TB, Sherstnev MP (1992) Enhancement of chemiluminescence associated with lipid peroxidation by rhodamine dyes. Free Radic Biol Med 12:43–52. https://doi.org/10.1016/0891-5849(92)90057-n
Vladimirov GK, Sergunova EV, Izmaylov DY, Vladimirov YA (2016) Chemiluminescent determination of total antioxidant capacity in medicinal plant material. Bull RSMU 2:62–68. https://doi.org/10.24075/brsmu.2016-02-10
Yu Z, Lou R, Pan W, Li N, Tang B (2020) Nanoenzymes in disease diagnosis and therapy. Chem Commun 56:15513–15524. https://doi.org/10.1039/D0CC05427E
Zavilgelsky GB, Shakulov RS (2018) Mechanisms and origin of bacterial biolumenescence. Mol Biol 52:935–947. https://doi.org/10.1134/s0026898418060186
Zhang Z, Lai J, Wu K, Huang X, Guo S, Zhang L, Liu J (2018) Peroxidase-catalyzed chemiluminescence system and its application in immunoassay. Talanta 180:260–270. https://doi.org/10.1016/j.talanta.2017.12.024
Zhidkova TV, Proskurnina EV, Parfenov EA, Vladimirov YA (2011) Determination of superoxide dismutase and SOD-mimetic activities by a chemical system: Co2+/H2O2/lucigenin. Anal Bioanal Chem 401:381–387. https://doi.org/10.1007/s00216-011-5070-8
Zvereva MV, Hiteva TV, Zhmurova AV (2023) Chemiluminescence analysis of the radical-scavenging capacity of arabinogalactan-stabilized silver nanoparticles. In: Collection of Scientific Works of the VII Congress of Biophysicists of Russia: in 2 volumes, volume 1 - Krasnodar: Printing house of FSBEI VPO "KubGTU", pp 415–416. https://doi.org/10.26297/SbR6.2023.001
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The study was supported by Russian Science Foundation (grant number 23-26-00140).
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Zvereva, M.V., Zhmurova, A.V. The use of a chemiluminescence in the assessment of the nanomaterials antioxidant activity. Biophys Rev 15, 963–969 (2023). https://doi.org/10.1007/s12551-023-01148-4
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DOI: https://doi.org/10.1007/s12551-023-01148-4