Abstract
The study of the microbial community—the microbiome—associated with a human host is a maturing research field. It is increasingly clear that the composition of the human’s microbiome is associated with various diseases such as gastrointestinal diseases, liver diseases and metabolic diseases. Using high-throughput technologies such as next-generation sequencing and mass spectrometry–based metabolomics, we are able to comprehensively sequence the microbiome—the metagenome—and associate these data with the genomic, epigenomics, transcriptomic and metabolic profile of the host. Our review summarises the application of integrating host omics with microbiome as well as the analytical methods and related tools applied in these studies. In addition, potential future directions are discussed.
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Funding was provided by the National Natural Science Foundation of China (grant nos. 81330011, 81330014, 81790631, 81790633, 81570512 and 81121002), the Science Fund for Creative Research Groups of the National Natural Science Foundation of China (grant no. 81721091), and the National Basic Research Program of China (973 program) (grant no. 2013CB531401). This work was also supported in part by funds from the New South Wales Ministry of Health, a National Health and Medical Research Council Career Development Fellowship (1105271 to JWKH) and the National Heart Foundation (Future Leader Fellowship 100848 to JWKH and 101204 to EG).
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Qing Wang declares that she has no conflict of interest. Kaicen Wang declares that she has no conflict of interest. Wenrui Wu declares that she has no conflict of interest. Eleni Giannoulatou declares that she has no conflict of interest. Joshua W. K. Ho declares that he has no conflict of interest. Lanjuan Li declares that he/she has no conflict of interest.
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Wang, Q., Wang, K., Wu, W. et al. Host and microbiome multi-omics integration: applications and methodologies. Biophys Rev 11, 55–65 (2019). https://doi.org/10.1007/s12551-018-0491-7
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DOI: https://doi.org/10.1007/s12551-018-0491-7