Abstract
Pleomorphic adenoma is a benign tumor commonly involving the salivary glands and mainly the parotid gland. It affects the minor salivary glands with the palate being the most common site of occurrence. The involvement of the upper lip is considered rare with very few reports in the literature. Clinically it is a painless, non-erythematous, firm and slowly growing tumor. Microscopically it has a biphasic microscopic appearance with mixed epithelial and stromal components. Although it is benign the rate of malignant transformation is reported as being up to 4 % in long standing cases. The incidence of this tumor has been reported in various gender, ethnic and geographic groups. With the recent reports of the increase in the variations of location and the biological nature of the tumor the need for extensive research is more demanding. This case report presents a systematic approach to long standing pleomorphic adenoma affecting the upper lip.
Similar content being viewed by others
References
Debnath SC, Adhyapok AK. Pleomorphic adenoma (benign mixed tumour) of the minor salivary glands of the upper lip. J Maxillofac Oral Surg. 2010;9(2):205–8.
Shrestha A, Reddy NS, Ganguly SN. Pleomorphic adenoma of the upper lip: a case report. Nepal Med Coll J. 2011;6(1):51–3.
Dyalram D, Huebner T, Papadimitriou JC, Lubek J. Carcinoma ex pleomorphic adenoma of the upper lip. Int J Oral Maxillofac Surg. 2012;41:364–7.
Ali I, Gupta AK, Singh S. Pleomorphic adenoma of the upper lip. Natl J Maxillofac Surg. 2011;2:219–21.
Gomes CC, Diniz MG, Orsine LA, Duarte AP, Fonseca-Silva T. Assessment of TP53 mutations in benign and malignant salivary gland neoplasms. PLoS One. 2012;7:e41261.
Kataria SP, Talwar P, Sethi D, Garg M. Pleomorphic adenoma of the upper lip. J Cutan Aesthet Surg. 2011;3:217–9.
Lotufo MA, Júnior CA, Mattos JP, França CM. Pleomorphic adenoma of the upper lip in a child. J Oral Sci. 2008;50:225–8.
Sengul I, Sengul D, Aribas D. Pleomorphic adenoma of the lower lip: a rare site of location. N Am J Med Sci. 2011;3:299–301.
Asuquo ME, Otei OO, Ekpo R, Abang I, Adams U, Bassey EE, Ebughe G. Salivary gland tumour of the lip: report of two cases and literature review. Cent Afr J Med. 2009;55:43–6.
Hamakawa H, Takarada M, Ito C, Tanioka H. Bone-forming pleomorphic adenoma of the upper lip: report of a case. J Oral Maxillofac Surg. 1997;55:1471–5.
Pons Vicente O, Almendros Marqués N, Berini Aytés L, Gay Escoda C. Minor salivary gland tumors: a clinicopathological study of 18 cases. Med Oral Patol Oral Cir Bucal. 2008;13:582–8.
KüçüK U, Tan S. Pleomorphic adenoma of the upper lip. Turk Patoloji Derg. 2011;27:73–6.
Kuo YL, Tu TY, Chang CF, Li WY, Chang SY, Shiao AS, Chu PY, Chan KT, Tai SK, Wang YF, Kao SC, Kao SY, Lo WL, Wu CH, Shu WH, Ma S, Wang TH. Extra-major salivary gland pleomorphic adenoma of the head and neck: a 10-year experience and review of the literature. Eur Arch Otorhinolaryngol. 2011;268:1035–40.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Mohammed, I., Saghali, A., Ramasamy, S. et al. Systematic approach to long standing pleomorphic adenoma of the upper lip. J. Stomat. Occ. Med. 7, 53–56 (2014). https://doi.org/10.1007/s12548-013-0102-y
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12548-013-0102-y