Abstract
In this study, we investigated the formation behavior of spherical porous biphasic calcium phosphate (BCP) granules, in which PCL was both the binder and fugitive pore former. The formation of porous granules was based on the immiscibility of PCL slurry containing BCP powder and distilled water. The porosity was controlled by controlling the volume fraction of PCL. In addition, the effect of the composition on the rheological properties and consequently the droplet formation mechanism was examined. After drying and sintering, the resulting BCP granules had a porous structure, which could promote stronger cell in-growth behavior. The method developed in this study can be utilized to successfully fabricate granules with controlled porosity and size.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
M. Jarcho, Clin. Orthop. Relat. Res. 157, 259 (1981).
V. S. Komlev, S. M. Barinov, and E. V. Koplik, Biomater. 23, 3449 (2002).
C. Santos, M. A. Martins, R. P. Franke, M. M. Almeida, and M. E. V. Costa, Ceram. Inter. 35, 1587 (2009).
H. Maeda, and T. Kasuaga, Acta. Biomater. 2, 403 (2006).
P. Iooss, A. M. L. Ray, G. Grimandi, G. Daculsi, and C. Merle, Biomater. 22, 2785 (2001).
H. R. R. Ramay, and M. Zhang, Biomater. 25, 5171 (2004).
W. J. E. M. Habraken, J. G. C. Wolke, and J. A. Jansen, Advan. Dru. Deliv. Rev. 59, 234 (2007).
H. Yuan, M. V. D. Doel, S. Li, C. A. V. Blitterswijk, K. D. Groot, and J. D. De Bruijn, J. Mater. Sci: Mater. Med. 13, 1271 (2002).
W. Linhart, F. Peters, W. Lehmann, K Schwarz, A. F. Schilling, and M. Amlingl, J. Bio. Mater. Res. 54, 162 (2001).
M. Kamitakahara, C. Ohtsuki, M. Oishi, S. Ogata, T. Miyazaki, and M. Taniha, Bioceramics 17, 281 (2005).
K. D. Woo, D. S. Kang, M. S. Moon, S. H. Kim, Z. Liu, and A. N. Omran, Korean J. Met. Mater. 48, 369 (2010).
D. M. Liu, Biomater. 17, 1955 (1996).
K. Ioku, G. Kawachi, S. Sasaki, H. Fujimori, and S. Goto, J. Mater. Sci. 41, 1341 (2006).
S. Kmolev, S. M. Barinove, E. Girardin, S. Oscarsson, A. Rosengren, F. Rustichelli, and V. P. Orloveskii, J. Sci. Technol. Adv. Mat. 4, 503 (2003).
W. Paul and C. T. Sharma, J. Mater. Sci.: Mater. Med. 10, 383 (1999).
D. M. Newitt and J. M. Conway-Jones, Trans. I. Chem. Eng. 36, 422 (1958).
P. J. Sherrington and O. Oliver, Granulation, Heyden, London (1981).
B. T. Lee, M. H. Youn, R. K. Paul, K. H. Lee, and H. Y. Song, Mater. Chem. Phys. 104, 249 (2007).
S. Hatano, N. Nakamura, N. Kobayashi, Y. Itaya, S. Mori, and Y. Shimada, The 12 th Int. Conf. on Fluidization-New Horizons in Fluidization Eng., p.345, Vancouver, Canada (2007).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Sarkar, S.K., Tuyen, DV. & Lee, BT. Evaluation of formation process of spherical porous biphasic calcium phosphate (BCP) granules by slurry dripping method. Met. Mater. Int. 18, 717–721 (2012). https://doi.org/10.1007/s12540-012-4024-9
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12540-012-4024-9