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Regional hospitalisation and seasonal variations of Pediatric rotavirus gastroenteritis pre- and post-RV vaccination: a prospective and retrospective study

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Abstract

Background

Rotavirus is the primary cause of gastroenteritis in children worldwide and is a leading cause of gastroenteritis in children, with a significant burden. Rotavirus vaccine became available in Ireland in 2016. This study aimed to investigate hospital admissions and seasonal characteristics of rotavirus gastroenteritis in a pre- and post-vaccination period in a single district general hospital.

Methods

In the post-vaccination year, from November 18th 2016 to November 18th 2017, all children up to 3 years of age who presented to Mayo University Hospital with vomiting and diarrhea, were recruited and had their stool tested for rotavirus. Retrospective analysis of hospital data of children of the same age during pre-vaccination years (2014–2016) were used for comparison.

Results

Compared with the pre-vaccination years (2014–2016), the median percentages of reduction of rotavirus positive stool requests and hospital admissions were high, 48.5% and 73%, respectively. In the post-vaccination year, the median percentage of reduction of emergency department presentation (stool requests) with gastroenteritis was 9%. No delay in the onset of RV season or reduction of the peak of RV infection was noted in the post-vaccination year. The duration of rotavirus season in 2016/2017 was short.

Conclusions

Compared with 3 pre-vaccination years, the total number of gastroenteritis presentations, gastroenteritis hospital admissions, and rotavirus positive gastroenteritis cases were all reduced, and the duration of the rotavirus season was shorter.

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Data availability statement

Available upon reasonable request.

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Acknowledgements

I greatly thank Ms Zoe Yandle (Clinical Scientist at the National Virus Reference Laboratory-Dublin) for her kind assistance in relation to performing laboratory investigations and was happy with submission for publication.

Funding

None.

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Authors and Affiliations

  1. Consultant Paediatrician, South West Acute Hospital-Paediatric Department, 124 Irvinestown Rd, Enniskillen, BT, 74 6DN, Northern Ireland

    Zakaria Barsoum

Authors
  1. Zakaria Barsoum
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Contributions

ZB was responsible for conceptualization, study design, study protocol, data collection and management, literature search, writing original draft, review & editing, and submitting the final version of the manuscript.

Corresponding author

Correspondence to Zakaria Barsoum.

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Conflict of interest

No financial or non- financial benefits have been received or will be received from any part related directly or indirectly to the subject of this article.

Ethics approval

Obtained from Ethical Committee at Mayo University Hospital prior to study commencement (Ref TOM/DP).

Consent to participate

Obtained from carers of children.

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Barsoum, Z. Regional hospitalisation and seasonal variations of Pediatric rotavirus gastroenteritis pre- and post-RV vaccination: a prospective and retrospective study. World J Pediatr 18, 404–416 (2022). https://doi.org/10.1007/s12519-022-00546-0

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  • DOI: https://doi.org/10.1007/s12519-022-00546-0

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