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Elevated serum levels of ghrelin and TNF-α in patients with cyanotic and acyanotic congenital heart disease

  • Meta-analysis
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Abstract

Background

The levels of ghrelin and tumor necrosis factor alpha (TNF-α) are considered biological markers of congenital heart diseases (CHD). The present meta-analysis was conducted to investigate the clinical significance of serum levels of ghrelin and TNF-α in children with (CHD).

Methods

Chinese and English scientific literature databases were searched to retrieve published studies relevant to ghrelin, TNF-α and CHD. Manual search was additionally employed to identify other relevant studies from cross-references. The retrieved studies were screened on the basis of our stringent inclusion and exclusion criteria to select high quality case-control studies for meta-analysis.

Results

We initially retrieved 108 published studies (20 in Chinese and 88 in English) from database searches. Finally, 6 case-control studies (5 in English and 1 in Chinese) were enrolled in our meta-analysis, and contained a total of 160 cyanotic congenital heart disease (CCHD) patients and 215 acyanotic congenital heart disease (ACHD) patients, along with 162 healthy controls. The results of meta-analysis showed that serum levels of ghrelin and TNF-α in CCHD or ACHD children were significantly higher than those in healthy controls.

Conclusions

Our meta-analysis results showed that serum levels of ghrelin and TNF-α are elevated in children with CHD, and could be used as effective biologic markers in early diagnosis of CHD.

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Acknowledgements

We would like to acknowledge the reviewers for their great advice on this paper.

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Authors and Affiliations

  1. Outpatient Department of Pediatrics, No.1 Hospital of Jilin University, Xinmin Street No.71, Changchun, 130021, China

    Sai Zhang & Li-Qun Sun

  2. Department of Cardiology, the Third Hospital of Jilin University, Changchun, China

    Gong-Liang Guo

  3. Department of Gynecology and Obstetrics, No.1 Hospital of Jilin University, Changchun, China

    Li-Li Yang

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  1. Sai Zhang
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  4. Li-Qun Sun
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Correspondence to Li-Qun Sun.

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Zhang, S., Guo, GL., Yang, LL. et al. Elevated serum levels of ghrelin and TNF-α in patients with cyanotic and acyanotic congenital heart disease. World J Pediatr 13, 122–128 (2017). https://doi.org/10.1007/s12519-016-0068-0

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  • DOI: https://doi.org/10.1007/s12519-016-0068-0

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