We thank the participants of these studies. Glecaprevir was identified by AbbVie and Enanta.
Funding
AbbVie funded this study and participated in the study design, research, analysis, data collection, interpretation of data, reviewing, and approval of the publication. AbbVie funded the journal’s Rapid Service and Open Access of this publication.
Medical Writing Assistance
Medical writing support was provided by Annie Massa, MBiolSci, and Tom Owen, PhD, of Fishawack Communications, Ltd; and funded by AbbVie.
Authorship
All named authors meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship for this article, take responsibility for the integrity of the work as a whole, and have given their approval for this version to be published. All authors had access to relevant data and participated in the drafting, review, and approval of this publication. No honoraria or payments were made for authorship.
Authors’ Contributions
SP, KC, JH, JH, PL, AB, and SCG contributed to the collection of data, drafting and editing of the manuscript. XF, JJF, MB, MB, JM, and IJ contributed to the analysis concept and methodology, collection of data, drafting and editing of the manuscript. DED, FT, and JM contributed to the analysis concept and methodology, drafting and editing of the manuscript. AE and ZZ contributed to analysis methodology, statistical analysis, drafting and editing of the manuscript.
Disclosures
Xavier Forns: Honoraria for consulting/speaking: AbbVie and Gilead. Jordan J. Feld: Research support/consultant: AbbVie, Arbutus, Eiger, Enanta, Gilead, GSK, Janssen, and Roche. Stanislas Pol: has received consulting and lecturing fees from Janssen, Gilead, MSD, AbbVie, Biotest, Shinogui, Roche, ViiV and grants from Gilead, Roche, and MSD. Kazuaki Chayama: Honoraria for teaching: AbbVie, Bristol-Myers Squibb, Dainippon Sumitomo, Eizai, Gilead, Mitsubishi Tanabe, MSD, and Otsuka; research funding from AbbVie and Bristol-Myers Squibb. Jinlin Hou: Consulting fees from AbbVie, Arbutus Biopharma, Bristol-Myers Squibb, Gilead Sciences, Johnson & Johnson, and Roche; grants from Bristol-Myers Squibb and Johnson & Johnson. Douglas E. Dylla, Mark Bondin, Fernando Tatsch, Margaret Burroughs, John Marcinak, Zhenzhen Zhang, Amanda Emmett: Employees of AbbVie and may hold stock/share options. Jeong Heo: Research support from Roche; advisor for AbbVie, Bristol-Myers Squibb, and Gilead Sciences. Pietro Lampertico: Speaker bureau and/or advisory board: AbbVie, Alnylam, Arrowhead, Bristol-Myers Squibb, Eiger BioPharmaceuticals, Gilead Sciences, GSK, Janssen, MSD, MYR Pharmaceuticals, Roche, and Spring Bank. Ashley Brown: Investigator, speaker honoraria, and advisor: AbbVie. Stuart C. Gordon: Grant/research support: AbbVie, Gilead, and Merck. Ira M Jacobson: Grant/research support: Assembly Biosciences, Bristol-Myers Squibb, Durect, Eli Lilly, Enanta, Gilead, Genfit, and Janssen; consultant/advisor: AbbVie, Arbutus Arrowhead, Atea, Assembly Biosciences, Bristol-Myers Squibb, Intercept, Janssen, Gilead, GSK, Merck, Novo Nordisk, Redhill.
Compliance with Ethics Guidelines
For all included studies, written informed consent was obtained from each patient, including consent to participate and permission to publish personal health information while maintaining the identity of the individual confidential. For all included studies, the study protocols conformed to the ethical guidelines of the 1964 Declaration of Helsinki and its later amendments, and were approved by the appropriate institutional review boards.
Data Availability
This clinical trial data can be requested by any qualified researchers who engage in rigorous, independent scientific research, and will be provided following review and approval of a research proposal and Statistical Analysis Plan (SAP) and execution of a Data Sharing Agreement (DSA). Data requests can be submitted at any time and the data will be accessible for 12 months, with possible extensions considered. For more information on the process, or to submit a request, visit the following link: https://www.abbvie.com/our-science/clinical-trials/clinical-trials-data-and-information-sharing/data-and-information-sharing-with-qualified-researchers.html.