We thank the participants included in these studies. Dave Singh is supported by the National Institute for Health Research (NIHR) Manchester Biomedical Research Centre (BRC).
Support for this project and the journal’s Open Access Fee were funded by Boehringer Ingelheim International GmbH. No Rapid Service Fee was received by the journal for the publication of this article.
The authors meet criteria for authorship as recommended by the International Committee of Medical Journal Editors. They take full responsibility for the scope, direction, content of, and editorial decisions relating to the manuscript, were involved at all stages of development and have approved the submitted manuscript. The authors received no compensation related to the development of the manuscript.
Klaus F. Rabe reports personal fees from Boehringer Ingelheim, AstraZeneca, Novartis and Chiesi, and grants from Boehringer Ingelheim, AstraZeneca and Takeda, outside the submitted work. James D. Chalmers has received grants and personal fees from AstraZeneca, Boehringer Ingelheim, GSK, Grifols, Insmed, Novartis and Zambon, grants from Gilead and personal fees from Napp, outside the submitted work. Marc Miravitlles has received speaker fees from AstraZeneca, Boehringer Ingelheim, Chiesi, Cipla, Menarini, Rovi, Bial, Sandoz, Zambon, CSL Behring, Grifols and Novartis, consulting fees from AstraZeneca, Boehringer Ingelheim, Chiesi, GlaxoSmithKline, Bial, Gebro Pharma, Kamada, CSL Behring, Laboratorios Esteve, Ferrer, Mereo Biopharma, Verona Pharma, TEVA, Spin Therapeutics, pH Pharma, Novartis, Sanofi and Grifols and research grants from GlaxoSmithKline and Grifols, outside the submitted work. Janwillem W.H. Kocks has received grants and personal fees from AstraZeneca, Boehringer Ingelheim and GSK, grants from Chiesi, and personal fees from Mundipharma and Teva, outside the submitted work. Ioanna Tsiligianni has received grants and personal fees from GSK, grants from ELPEN and personal fees from Boehringer Ingelheim, Menarini and Novartis, outside the submitted work. Alberto de la Hoz and Wenqiong Xue are employees of Boehringer Ingelheim. Dave Singh reports personal fees from Apellis, Cipla, Genentech, Peptinnovate and Skyepharma, and grants and personal fees from AstraZeneca, Boehringer Ingelheim, Chiesi, Glenmark, Merck, Mundipharma, Novartis, Pfizer, Pulmatrix, Teva, Theravance and Verona, outside the submitted work. Gary T. Ferguson has received grants, personal fees and non-financial support from AstraZeneca, Boehringer Ingelheim, GSK, Novartis, Pearl Therapeutics, Sunovion and Theravance, and personal fees from Circassia, Innoviva, Mylan and Verona, outside the submitted work. Jadwiga Wedzicha has received grants from AstraZeneca, Boehringer Ingelheim, Chiesi, GSK, Johnson and Johnson, and Novartis, and meeting expenses from AstraZeneca, Boehringer Ingelheim, GSK and Novartis, outside the submitted work.
Medical Writing, Editorial, and Other Assistance
Medical writing assistance, in the form of the preparation and revision of the manuscript, was supported financially by Boehringer Ingelheim and provided by Vicki Cronin, PhD, at MediTech Media, under the authors’ conceptual direction and based on feedback from the authors.
Compliance with Ethics Guidelines
The TONADO® studies were performed in accordance with the Declaration of Helsinki, International Conference on Harmonisation Harmonised Tripartite Guideline for Good Clinical Practice and local regulations. The protocols were approved by the authorities and the ethics committees of the respective institutions, and signed informed consent was obtained from all patients.
The data sets used and analysed during the current study are available from the corresponding author on reasonable request. Before this request, users should get permission from the local ethics committee.