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Anti-tumor Effects of Polyphenols via Targeting Cancer Driving Signaling Pathways: A Review

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Abstract

The use of drugs in chemotherapy poses numerous side effects. Hence the use of natural substances that can help in the prevention and cure of the disease is a dire necessity. Cancer is a deadly illness and combination of diseases, the menace of which is rising with every passing year. The research community and scientists from all over the world are working towards finding a cure of the disease. The use of polyphenols which are naturally derived from plants have a great potential to be used as anti-cancer drugs and also the use of fruits and vegetables which are rich in these polyphenols can also help in the prevention of diseases. The study aims to compile the available literature and research studies on the anti-cancer effects of polyphenols and the signaling pathways that are affected by them. To review the anti-cancer effects of polyphenols, Google Scholar, PubMed and ScienceDirect were used to study the literature available. The article that have been used for literature review were filtered using keywords including cancer, polyphenols and signaling pathways. Majorly articles from the last 10 years have been considered for the review but relevant articles from earlier than 10 years have also been considered. Almost 400 articles were studied for the review and 200 articles have been cited. The current review shows the potential of polyphenols as anti-cancer compounds and how the consumption of a diet rich in polyphenols can help in the prevention of cancer. Because of their capacity to affect a variety of oncogenic and oncosuppressive signaling pathways, phytochemicals derived from plants have been effectively introduced as an alternative anticarcinogenic medicines.

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Acknowledgements

KM is a recipient of junior research fellowship from Haryana State Council for Science, Innovation and Technology (HSCIT-3946). This agency had no role in the interpretation or writing the manuscript. AP is a recipient of junior research fellowship from The Indian Council of Medical Research (ICMR), Government of India (5/10/FR/03/2021-RBMCH). The Indian Council of Medical Research (ICMR), Government of India, is gratefully acknowledged by PKM for giving financial assistance (5/10/FR/03/2021-RBMCH).

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  1. Department of Biochemistry, Central University of Haryana, Mahendergarh, 123031, India

    Kareena Moar, Somu Yadav, Anuja Pant,  Deepika & Pawan Kumar Maurya

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KM: Conceptualization, Writing—Original draft preparation; SY: Writing and Editing; AP: Writing and Editing; D: Writing and Editing; PKM: Supervision, Reviewing and Editing.

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Correspondence to Pawan Kumar Maurya.

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Moar, K., Yadav, S., Pant, A. et al. Anti-tumor Effects of Polyphenols via Targeting Cancer Driving Signaling Pathways: A Review. Ind J Clin Biochem (2024). https://doi.org/10.1007/s12291-024-01222-y

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