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Angiogenic Potential, Circulating Angiogenic Factors and Insulin Resistance in Subjects with Obesity

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Abstract

Altered vascular function and pathological angiogenesis are important factors common to the development of obesity and obesity-associated diseases. Most human studies relating obesity and angiogenesis have compared levels of angiogenic factors in obesity without looking at the serum angiogenic capacity which reflects the balance between the effects of angiogenic and angiostatic factors. Therefore, in this cross-sectional study, the serum angiogenic potential and levels of angiogenic factors in serum of obese (BMI > 25 kg/m2) and lean subjects (BMI < 23 kg/m2), with no history of obesity associated co-morbidities, were assessed. Serum angiogenic potential was significantly higher (p < 0.0001) in both male (n = 67) and female (n = 35) obese subjects and showed a positive correlation (r = 0.4, p < 0.0001) with BMI. Serum levels of the angiogenic factors, vascular endothelial growth factor (VEGF) and angiopoietin were significantly higher in obese subjects. Levels of angiostatic factors such as angiostatin, endostatin were not altered in obese male subjects but were elevated in female obese subjects. Angiogenic potential and levels of VEGF did not vary in obese subjects with high HOMA-IR compared to obese subjects with low HOMA-IR. These results suggest that the angiogenic potential of serum was elevated in obesity and that insulin resistance may not contribute to the increased angiogenic potential in obesity.

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Acknowledgements

The study was supported by financial assistance in the form of a TSS fellowship from ICMR, New Delhi to MS. Support from the Medical superintendent and staff of Sri Ramachandra Medical college hospital in collection of samples is gratefully acknowledged.

Funding

The study was supported by financial assistance in the form of a TSS fellowship from Indian Council for Medical Research, New Delhi to Manu Sudhakar.

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Authors and Affiliations

  1. Department of Biochemistry, Sri Ramachandra Medical College and Research Institute, Chennai, Tamil Nadu, India

    Manu Sudhakar & Santhi Silambanan

  2. Inter University Centre for Genomics and Gene Technology, Department of Biotechnology, University of Kerala, Thiruvananthapuram, Kerala, India

    Athira A. Prabhakaran

  3. Department of Surgery, Sri Ramachandra Medical College and Research Institute, Chennai, Tamil Nadu, India

    Ramya Ramakrishnan

Authors
  1. Manu Sudhakar
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  2. Santhi Silambanan
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  3. Athira A. Prabhakaran
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  4. Ramya Ramakrishnan
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Correspondence to Manu Sudhakar.

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Conflict of interest

The authors Manu Sudhakar, Santhi Silambanan, Athira. A. Prabhakaran, and Ramya Ramakrishnan declare that they have no conflict of interest.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Sudhakar, M., Silambanan, S., Prabhakaran, A.A. et al. Angiogenic Potential, Circulating Angiogenic Factors and Insulin Resistance in Subjects with Obesity. Ind J Clin Biochem 36, 43–50 (2021). https://doi.org/10.1007/s12291-019-0816-8

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  • DOI: https://doi.org/10.1007/s12291-019-0816-8

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