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Lysyl Oxidase: Its Diversity in Health and Diseases

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Abstract

The mechanical properties of extracellular matrix (ECM) and connective tissues is largely dependent on the collagen and elastin structure. Lysyl oxidase (LOX) plays a critical role in the formation and repair of the ECM by oxidizing lysine residues in elastin and collagen, thereby initiating the formation of covalent cross linkages which stabilize these fibrous proteins. Due to its multiple functions both extracellularly and intracellularly, lysyl oxidase is involved in several processes in the tumorigenic pathway, in many different cancer types and stages. Alteration in LOX activity is implicated in many diseases and disorders including inflammation and inflammatory diseases, fibrosis of distinct organs and fibrotic disorders, cancer promotion and progression. There are only sparse reports of mutations or epigenetic alterations in the LOX gene. This review provides the recent clinical developments in the molecular mechanisms and pathologic process, pointing out LOX as a potential therapeutic target in translational medicine.

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Authors and Affiliations

  1. Department of Biochemistry, All India Institute of Medical Sciences (AIIMS), Bhubaneswar, India

    Suchitra Kumari

  2. SCB Medical College and Hospital, Cuttack, India

    Tarun Kumar Panda

  3. Department of Biochemistry, KIMS, Bhubaneswar, India

    Tapaswini Pradhan

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  1. Suchitra Kumari
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  3. Tapaswini Pradhan
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Correspondence to Suchitra Kumari.

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Authors Dr. Suchitra Kumari, Dr. Tarun Kumar Panda, Dr Tapaswini Pradhan have no conflict of interest.

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This article does not contain any studies with human participants or animals performed by any of the authors.

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For this type of study formal consent is not required. This article does not contain any studies with human participants or animals performed by any of the authors.

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Kumari, S., Panda, T.K. & Pradhan, T. Lysyl Oxidase: Its Diversity in Health and Diseases. Ind J Clin Biochem 32, 134–141 (2017). https://doi.org/10.1007/s12291-016-0576-7

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  • DOI: https://doi.org/10.1007/s12291-016-0576-7

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