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Troponin T and Heart Type Fatty Acid Binding Protein (h-Fabp) as Biomarkers in Patients Presenting with Chest Pain

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Abstract

Acute coronary syndrome (ACS) is a term for a range of clinical signs and symptoms suggestive of myocardial ischemia. It results in functional and structural changes and ultimately releasing protein from injured cardiomyocytes. These cardiac markers play a major role in diagnosis and prognosis of ACS. This study aims to assess the efficacy of heart type fatty acid binding protein (h-FABP) as a marker for ACS along with the routinely used hs-TropT. In our observational study, plasma h-FABP (cut-off 6.32 ng/ml) and routinely done hs-Trop T (cutoff 0.1 and 0.014 ng/ml) were estimated by immunometric laboratory assays in 88 patients with acute chest pain. Based on the clinical and laboratory test findings the patients were grouped into ACS (n = 41) and non-ACS (n = 47). The diagnostic sensitivity, specificity, NPV, PPV and ROC curve at 95 % CI were determined. Sensitivity of hs-TropT (0.1 ng/ml), hs-TropT (0.014 ng/ml) and h-FABP were 53, 86 and 78 % respectively and specificity for the same were 98, 73 and 70 % respectively. Sensitivity, specificity and NPV calculated for a cut-off combination of hs-TropT 0.014 ng/ml and h-FABP was 100, 51 and 100 % respectively. These results were substantiated by ROC analysis. Measurement of plasma h-FABP and hs-TropT together on admission appears to be more precise predictor of ACS rather than either hs-Trop T or h-FABP.

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Acknowledgments

We acknowledge P. D Hinduja National Hospital & Medical Research Centre for their continued encouragement and Randox laboratories India Pvt. Ltd. for support in terms of reagents for the study.

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Authors and Affiliations

  1. Research Laboratories, P. D. Hinduja National Hospital & Medical Research Centre, Veer Savarkar Marg, Mahim, Mumbai, 400016, India

    Lakshmi Lavanya Reddy

  2. Department of Biochemistry, Department of Laboratory Medicine, P. D. Hinduja National Hospital & Medical Research Centre, Veer Savarkar Marg, Mahim, Mumbai, 400016, India

    Swarup A. V. Shah, Alpa J. Dherai & Tester F. Ashavaid

  3. Department of Cardiology, P. D. Hinduja National Hospital & Medical Research Centre, Veer Savarkar Marg, Mahim, Mumbai, 400016, India

    Chandrashekhar K. Ponde

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  1. Lakshmi Lavanya Reddy
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  2. Swarup A. V. Shah
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  5. Tester F. Ashavaid
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Correspondence to Tester F. Ashavaid.

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Reddy, L.L., Shah, S.A.V., Dherai, A.J. et al. Troponin T and Heart Type Fatty Acid Binding Protein (h-Fabp) as Biomarkers in Patients Presenting with Chest Pain. Ind J Clin Biochem 31, 87–92 (2016). https://doi.org/10.1007/s12291-015-0492-2

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  • DOI: https://doi.org/10.1007/s12291-015-0492-2

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