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Clinico-Biochemical Correlation Between Psoriasis and Insulin Resistance

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Abstract

Psoriasis is a chronic inflammatory disease associated with an increased insulin resistance, obesity and cardiovascular risk. The present study was aimed to assess insulin resistance and pattern of body fat deposition in psoriasis. Body mass index (BMI) and waist circumference (WC) were measured in 40 psoriatic patients and 46 age- and sex-matched control subjects. Fasting blood glucose (FBG) and serum insulin level were measured by standard photometric method and ELISA respectively. HOMA-IR (homeostatic model of insulin resistance) was calculated by appropriate software. The results indicated that case and control groups were comparable in terms of age and sex (p = 0.934) with an increased prevalence of psoriasis among male subjects (60 %). FBG and mean WC between the two groups were statistically not significant (p value = 0.271 and 0.21 respectively). BMI was significantly higher in case group compared to the control group (p = 0.049). Serum insulin level and insulin resistance in the psoriatic patients were significantly higher (p value <0.001). Multiple regression analysis revealed that insulin resistance (measured by HOMA) was dependent on BMI and WC at a significance level of p < 0.001 and 0.043 respectively. Therefore, the psoriatic patients in this region have significantly high amount of fasting serum insulin level along with an increased IR though their FBG level remains normal. Furthermore, these abnormalities are significantly dependent on total body fat as well as abdominal fat deposits. We suggest that psoriatic patients need to be evaluated for metabolic syndrome and managed accordingly.

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Author notes

  1. Suparna Dhara

    Present address: Department of Biochemistry, Calcutta National Medical College, Kolkata, 700014, India

Authors and Affiliations

  1. Department of Biochemistry, Burdwan Medical College, Burdwan, 713104, India

    Suparna Dhara

  2. Department of Biochemistry, Calcutta National Medical College, Kolkata, 700014, India

    Anindya Dasgupta & Ushasi Banerjee

  3. Department of Biochemistry, R G Kar Medical College, Kolkata, India

    Jayanta Kumar Rout

  4. Department of Biochemistry, N R S Medical College, Kolkata, India

    Sayantan Dasgupta

  5. Department of Gynaecology & Obstetrics, Burdwan Medical College, Burdwan, India

    Arindam Ghosh

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  1. Suparna Dhara
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  2. Anindya Dasgupta
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  3. Jayanta Kumar Rout
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  4. Ushasi Banerjee
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  5. Sayantan Dasgupta
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  6. Arindam Ghosh
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Correspondence to Suparna Dhara.

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Dhara, S., Dasgupta, A., Rout, J.K. et al. Clinico-Biochemical Correlation Between Psoriasis and Insulin Resistance. Ind J Clin Biochem 30, 99–103 (2015). https://doi.org/10.1007/s12291-013-0413-1

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  • DOI: https://doi.org/10.1007/s12291-013-0413-1

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