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A Study on Influence of Donor Hematocrit on the Procedural Parameters of Concentrated Single Donor Platelets Collected by Two Apheresis Devices

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Indian Journal of Hematology and Blood Transfusion Aims and scope Submit manuscript

Abstract

With improvements in apheresis collection, platelet additive solution (PAS) is steadily replacing plasma as the storage medium in single donor platelets (SDP). Concentrating platelets in SDP with one-third of plasma and two-thirds of PAS is referred as Concentrated-SDP (C-SDP). We studied the influence of donor hematocrit (Hct) in C-SDP procedures. A retrospective study, consisting of 124 and 95 plateletpheresis donors in MCS+ and Trima respectively. We compared two apheresis equipments MCS+ and Trima with regard to donor hematocrit on procedural parameters such as collection efficiency (CE), collection rate (CR), yield per hour (Y/H), yield per litre (Y/L) and percentage blood volume processed (%BV) during C-SDP procedures. Donors were categorized into two groups with Group A (Hct ≤ 46%) and Group B (Hct > 46%) based on mean baseline Hct of the study population. Among the 219 procedures, the overall CE was significantly higher for Trima over MCS+ equipment (77 vs 56, P < 0.001). However, there was no difference in procedural outcomes like CE, Y/L, Y/H, CR with MCS+ or Trima equipment between groups. %BV processed had a negative correlation with hematocrit in MCS+ (r = − 0.305, P = 0.001) and no difference was observed with Trima equipment. Donor Hct influences C-SDP collection only in processed blood volume with MCS+ equipment. Trima had statistically better performance over MCS+ equipments in all procedural parameters during C-SDP procedures. The data will guide apheresis centre to choose equipments based on donor characteristics.

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Acknowledgements

Authors acknowledge the staff of the blood bank and Mr. Riyas for statistical analysis.

Funding

This research did not receive any specific grant from funding agencies in the public, commercial or not-for-profit sector.

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Authors and Affiliations

  1. Department of Transfusion Medicine, Malabar Cancer Centre, Thalassery, Kerala, India

    Gayathiri K. Chellaiya & M. Murugesan

  2. Department of Oncopathology, Malabar Cancer Centre, Thalassery, Kerala, India

    Sangeetha K. Nayanar

Authors
  1. Gayathiri K. Chellaiya
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  2. M. Murugesan
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  3. Sangeetha K. Nayanar
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Correspondence to M. Murugesan.

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The authors declare that they have no competing interests.

Ethical Approval

Being retrospective study, Institutional Review Board (IRB) approved the present study without ethical approval through Ref. No: 1616/1RB-SRC/13/MCC/8-12-2018/2 dated: 20th December 2018.

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Chellaiya, G.K., Murugesan, M. & Nayanar, S.K. A Study on Influence of Donor Hematocrit on the Procedural Parameters of Concentrated Single Donor Platelets Collected by Two Apheresis Devices. Indian J Hematol Blood Transfus 36, 135–140 (2020). https://doi.org/10.1007/s12288-019-01163-0

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