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A comparison of clinicopathological characteristics and long-term survival outcomes between symptomatic and screen-detected breast cancer in Japanese women

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A Correction to this article was published on 10 January 2018

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Abstract

Background

Several studies from other countries have reported that patients with screen-detected breast cancer have better survival than those with symptomatic breast cancer. However, no such comparison has been performed in Japan. Therefore, we aimed to compare the clinicopathological characteristics and survival rates between symptomatic and screen-detected breast cancer in Japanese women.

Methods

From January 2000 to December 2004, 977 and 182 women with symptomatic or screen-detected breast cancer, respectively, underwent surgery at a single Japanese hospital. We retrospectively reviewed these patients’ clinicopathological data. Likelihood of death was estimated using the Kaplan–Meier method and the log-rank test. Multivariate analysis including mode of detection, tumor size, lymph node status, hormone receptor status, and adjuvant therapy administration was performed using the Cox proportional hazards model.

Results

Screen-detected breast cancer was associated with increased rate of breast-conserving surgery, non-invasive carcinoma, smaller tumor size, decreased lymph node involvement, increased hormone receptor positivity, and decreased adjuvant chemotherapy administration. Compared to women with symptomatic tumors, those with screen-detected tumors had improved overall and breast cancer-specific survival rates. Factors associated with survival in univariate analysis were screen detection, tumor size, lymph node status, progesterone receptor status, and adjuvant chemotherapy administration.

Conclusions

Breast cancer screening in Japanese women has led to increases in the rates of breast-conserving surgery, hormone receptor positivity, and survival rates along with reductions in axillary lymph node dissection and adjuvant chemotherapy administration.

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Change history

  • 10 January 2018

    In the original publication of this article, Table 1 was published incorrectly with rows out of order under “Distant metastasis (n, %)”.

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Authors and Affiliations

  1. Department of Breast and Endocrine Surgery, Kanagawa Cancer Center, 232 Nakao, Asahi-ku, Yokohama, Japan

    Hitoshi Inari, Satoru Shimizu, Nobuyasu Suganuma, Tatsuya Yoshida & Takashi Yamanaka

  2. Department of Surgery, Yokohama City University, 39 Fukuura, Kanazawa-ku, Yokohama, Japan

    Hirotaka Nakayama, Ayumi Yamanaka, Yasushi Rino & Munetaka Masuda

Authors
  1. Hitoshi Inari
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  2. Satoru Shimizu
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  3. Nobuyasu Suganuma
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  4. Tatsuya Yoshida
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  5. Hirotaka Nakayama
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  6. Takashi Yamanaka
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  7. Ayumi Yamanaka
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  8. Yasushi Rino
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  9. Munetaka Masuda
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Corresponding author

Correspondence to Hitoshi Inari.

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Conflict of interest

The authors declare that there are no conflicts of interest associated with this study, and that the trial was conducted independently.

Additional information

A correction to this article is available online at https://doi.org/10.1007/s12282-018-0832-1.

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Inari, H., Shimizu, S., Suganuma, N. et al. A comparison of clinicopathological characteristics and long-term survival outcomes between symptomatic and screen-detected breast cancer in Japanese women. Breast Cancer 24, 98–103 (2017). https://doi.org/10.1007/s12282-016-0678-3

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  • DOI: https://doi.org/10.1007/s12282-016-0678-3

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