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Radiation recall dermatitis induced by trastuzumab

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Abstract

We report a case of radiation recall dermatitis caused by trastuzumab. A 55-year-old woman with metastatic breast cancer received palliative first-line trastuzumab/paclitaxel and a salvage partial mastectomy with lymph node dissection was subsequently performed. In spite of the palliative setting, the pathology report indicated that no residual carcinoma was present, and then she underwent locoregional radiotherapy to ensure a definitive response. After radiotherapy, she has maintained trastuzumab monotherapy. Nine days after the fifth cycle of trastuzumab monotherapy, dermatitis in previously irradiated skin developed, with fever. Radiation recall dermatitis triggered by trastuzumab is extremely rare. A high fever developed abruptly with a skin rash. This may be the first case of this sort to be reported.

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Authors and Affiliations

  1. Department of Internal Medicine, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul, 120-752, Republic of Korea

    Dochang Moon, Chang Yun Yoon, Jaehyun Bae & Soohyeon Lee

  2. Department of Pathology, Yonsei University College of Medicine, Seoul, Republic of Korea

    Ja Seung Koo

  3. Department of Radiation Oncology, Yonsei University College of Medicine, Seoul, Republic of Korea

    Chang-Ok Suh

  4. Division of Medical Oncology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea

    Soohyeon Lee

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  1. Dochang Moon
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  2. Ja Seung Koo
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  3. Chang-Ok Suh
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  4. Chang Yun Yoon
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  5. Jaehyun Bae
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Correspondence to Soohyeon Lee.

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Moon, D., Koo, J.S., Suh, CO. et al. Radiation recall dermatitis induced by trastuzumab. Breast Cancer 23, 159–163 (2016). https://doi.org/10.1007/s12282-013-0462-6

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  • DOI: https://doi.org/10.1007/s12282-013-0462-6

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