Skip to main content

Advertisement

SpringerLink
Log in

Docetaxel and cyclophosphamide chemotherapy induced radiation recall phenomenon in a postoperative breast cancer patient: a case report

  • Case report
  • Published:
International Cancer Conference Journal Aims and scope Submit manuscript

Abstract

The radiation recall phenomenon (RRP) is an acute inflammatory reaction at a site previously treated with radiation, and is triggered by anti-cancer therapies such as chemotherapy or antibiotics. A 48-year-old Japanese woman with primary breast cancer underwent partial mastectomy and sentinel lymph node biopsy followed by postoperative radiotherapy. Subsequent to breast-conserving surgery, adjuvant chemotherapy, including docetaxel in combination with cyclophosphamide (TC), was administrated after 16 days of radiotherapy involving the right breast. The patient experienced the RRP with erythema and burning pain at the site of the irradiation fields at 6 days after the administration of TC. The skin symptoms resolved after treatment with topical corticosteroid therapy over a few days. After the second course of TC, the patient had only mild symptoms relative to the first course. She successfully completed four cycles of TC without dose reduction and treatment delay. We report this case involving the RRP induced by TC together with a review of the literature.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Burris HA 3rd, Hurtig J (2010) Radiation recall with anticancer agents. Oncologist 15:1227–1237

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. D’Angio G, Farber S, Maddock C (1959) Potentiation of X-ray effects by actinomycin D. Radiology 73:175–177

    Article  PubMed  Google Scholar 

  3. Camidge R, Price A (2001) Characterizing the phenomenon of radiation recall dermatitis. Radiother Oncol 59:237–245

    Article  CAS  PubMed  Google Scholar 

  4. Haffty BG, Vicini FA, Beitsch P et al (2008) Timing of chemotherapy after MammoSite radiation therapy system breast brachytherapy: analysis of the American Society of Breast Surgeons MammoSite breast brachytherapy registry trial. Int J Radiat Oncol Biol Phys 72:1441–1448

    Article  PubMed  Google Scholar 

  5. Stein RS (1978) Radiation-recall enteritis after actinomycin-D and adriamycin therapy. South Med J 71:960–961

    Article  CAS  PubMed  Google Scholar 

  6. Cassady JR, Richter MP, Piro AJ et al (1975) Radiation–adriamycin interactions: preliminary clinical overvations. Cancer 36:946–949

    Article  CAS  PubMed  Google Scholar 

  7. Hill AB, Tattersall SF (1983) Recall of radiation pneumonitis after intrapleural administration of doxorubicin. Med J Aust 1:39–40

    CAS  PubMed  Google Scholar 

  8. Ma LD, Taylor GA, Wharam MD et al (1993) “Recall” pneumonitis: adriamycin potentiation of radiation pneumonitis in two children. Radiology 187:465–467

    Article  CAS  PubMed  Google Scholar 

  9. Jimeno A, Ciruelos EM, Castellano D et al (2003) Radiation recall dermatitis induced by pegylated liposomal doxorubicin. Anticancer Drugs 14:575–576

    Article  CAS  PubMed  Google Scholar 

  10. Mizumoto M, Harada H, Asakura H et al (2006) Frequency and characteristics of docetaxel-induced radiation recall phenomenon. Int J Radiat Oncol Biol Phys 66:1187–1191

    Article  CAS  PubMed  Google Scholar 

  11. Yeo W, Leung SF, Johnson PJ (1997) Radiation-recall dermatitis with docetaxel: establishment of a requisite radiation threshold. Eur J Cancer 33:698–699

    Article  CAS  PubMed  Google Scholar 

  12. Borgia F, Guarneri C, Guarneri F et al (2005) Radiation recall dermatitis after docetaxel administration: absolute indication to replace the drug? Br J Dermatol 153:674–675

    Article  CAS  PubMed  Google Scholar 

  13. Culp LR, Pou AM, Jones DV et al (2004) A case of radiation recall mucositis associated with docetaxel. Head Neck 26:197–200

    Article  PubMed  Google Scholar 

  14. Kandemir EG, Karabudak O, Maydagli A (2005) Docetaxel-induced radiation recall dermatitis. Swiss Med Wkly 135:34–35

    PubMed  Google Scholar 

  15. Morkas M, Fleming D, Hahl M (2002) Challenges in oncology. Case 2. Radiation recall associated with docetaxel. J Clin Oncol 20:867–869

    PubMed  Google Scholar 

  16. Bokemeyer C, Lampe C, Heneka M et al (1996) Paclitaxel-induced radiation recall dermatitis. Ann Oncol 7:755–756

    Article  CAS  PubMed  Google Scholar 

  17. Phillips KA, Urch M, Bishop JF (1995) Radiation-recall dermatitis in a patient treated with paclitaxel. J Clin Oncol 13:305

    CAS  PubMed  Google Scholar 

  18. Schweitzer VG, Juillard GJ, Bajada CL et al (1995) Radiation recall dermatitis and pneumonitis in a patient treated with paclitaxel. Cancer 76:1069–1072

    Article  CAS  PubMed  Google Scholar 

  19. Saif MW, Black G, Johnson M et al (2006) Radiation recall phenomenon secondary to capecitabine: possible role of thymidine phosphorylase. Cancer Chemother Pharmacol 58:771–775

    Article  CAS  PubMed  Google Scholar 

  20. Ortmann E, Hohenberg G (2002) Treatment side effects. Case 1. Radiation recall phenomenon after administration of capecitabine. J Clin Oncol 20:3029–3030

    PubMed  Google Scholar 

  21. Friedlander PA, Bansal R, Schwartz L et al (2004) Gnemcitabine-related radiation recall preferentially involves internal tissue and organs. Cancer 100:1793–1799

    Article  PubMed  Google Scholar 

  22. Castellano D, Hitt R, Cortes-Funes H et al (2000) Side effects of chemotherapy. Case 2. Radiation recall reaction induced by gemcitabine. J Clin Oncol 18:695–696

    CAS  PubMed  Google Scholar 

  23. Fakih MG (2006) Gemcitabine-induced rectus abdominus radiation recall. JOP 7:306–310

    PubMed  Google Scholar 

  24. Ganem G, Solal-Celigny P, Joffroy A et al (2000) Radiation myositis: the possible role of gemsitabine. Ann Oncol 11:1615–1616

    Article  CAS  PubMed  Google Scholar 

  25. Jeter MD, Janne PA, Brooks S et al (2002) Gemcitabine-induced radiation recall. Int J Radiat Oncol Biol Phys 53:394–400

    Article  PubMed  Google Scholar 

  26. Saif MW, Sellers S, Russo S (2006) Gemcitabine-related radiation recallin a patient with pancreatic cancer. Anticancer Drugs 17:107–111

    Article  CAS  PubMed  Google Scholar 

  27. Borroni D, Vassallo C, Brazzelli V et al (2004) Radiation recall dermatitis, panniculitis, and myositis following cyclophosphamide therapy. Am J Dermatopathol 26:213–216

    Article  PubMed  Google Scholar 

  28. National Institutes of Health (2010) National Cancer Institute Common Terminology Criteria for Adverse Events Version 4.03, published June 14. http://ctep.cancer.gov/protocolDevelopment/electronic_applications/ctc.htm. Accessed 13 Nov 2015

Download references

Author information

Authors and Affiliations

  1. Department of Breast and Endocrine Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, Kumamoto, 860-8556, Japan

    Mai Tomiguchi, Yutaka Yamamoto, Mitsuhiro Hayashi, Mutsuko Yamamoto-Ibusuki, Keiichi Murakami & Hirotaka Iwase

  2. Department of Molecular-Targeting Therapy for Breast Cancer, Kumamoto University Hospital, 1-1-1 Honjo, Chuo-ku, Kumamoto, Kumamoto, 860-8556, Japan

    Mutsuko Yamamoto-Ibusuki

Authors
  1. Mai Tomiguchi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yutaka Yamamoto
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Mitsuhiro Hayashi
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Mutsuko Yamamoto-Ibusuki
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Keiichi Murakami
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Hirotaka Iwase
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Yutaka Yamamoto.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. This article does not contain any studies with animals performed by any of the authors.

Informed consent

Informed consent was obtained from all individual participants included in the study.

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Tomiguchi, M., Yamamoto, Y., Hayashi, M. et al. Docetaxel and cyclophosphamide chemotherapy induced radiation recall phenomenon in a postoperative breast cancer patient: a case report. Int Canc Conf J 5, 202–205 (2016). https://doi.org/10.1007/s13691-016-0258-6

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13691-016-0258-6

Keywords

Search

Navigation