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Near-infrared light-driven multifunctional metal ion (Cu2+)-loaded polydopamine nanomotors for therapeutic angiogenesis in critical limb ischemia

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Abstract

Most of the current nanomedicine-based treatments for critical limb ischemia (CLI) only aim at promoting angiogenesis, ignoring the negative influence on the therapeutic effects caused by the complex pathological micro-environment of ischemic tissue. Herein, near-infrared (NIR) light-driven metal ion (Cu2+)-loaded polydopamine (PDA) nanomotors (JMPN@Cu2+) is designed and prepared. Due to the good antioxidant and anti-inflammatory activities of PDA, JMPN@Cu2+ exhibits excellent biocompatibility and significantly improves the ischemic micro-environment. Additionally, based on superior photothermal conversion effect and jellyfish-like structure, the nanomotors are quickly propelled under NIR laser with low energy intensity to acquire the ability of movement and facilitate intracellular uptake of JMPN@Cu2+ by endothelial cells, resulting in the enhanced pro-angiogenic effect of Cu2+. Moreover, in vivo experimental findings show that JMPN@Cu2+ combined with NIR irradiation can successfully accelerate blood flow recovery and improve muscle repair. Taking these results together, this kind of nanomotor can promote angiogenesis along with ischemic micro-environment amelioration, holding great potential applications for the treatment of limb ischemia.

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Acknowledgements

This work was financially supported by the National Natural Science Foundation of China (No. 82170515), Open Research Fund of Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy (No. XZSYSKF2021038), Jiangsu Funding Program for Excellent Postdoctoral Talent, and Changzhou Municipal Health Commission Science and Technology Project (No. ZD202126).

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Author notes

  1. Liang Gui, Juju Huang, and Yi Xing contributed equally to this work.

Authors and Affiliations

  1. Department of Vascular Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China

    Liang Gui, Junjie Zou & Xiwei Zhang

  2. Department of Gastroenterology, The Affiliated Wuxi No.2 People’s Hospital of Nanjing Medical University, Wuxi, 214002, China

    Juju Huang & Yingwei Zhu

  3. Beijing Key Laboratory for Bioengineering and Sensing Technology, Department of Chemistry & Biological Engineering, University of Science & Technology, Beijing, 100083, China

    Yi Xing & Xin Du

  4. Department of Vascular Surgery, Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, 100730, China

    Yongjun Li

  5. Department of Anesthesiology, The Affiliated Wuxi No.2 People’s Hospital of Nanjing Medical University, Wuxi, 214002, China

    Xiao Liang

  6. Department of Intervention, Wujin Hospital Affiliated to Jiangsu University, Wujin Clinical College of Xuzhou Medical University, Changzhou, 213002, China

    Qiang Xu

  7. Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, 221004, China

    Qiang Xu

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  1. Liang Gui
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  10. Xin Du
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Corresponding authors

Correspondence to Xiwei Zhang, Qiang Xu or Xin Du.

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Near-infrared light-driven multifunctional metal ion (Cu2+)-loaded polydopamine nanomotors for therapeutic angiogenesis in critical limb ischemia

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Gui, L., Huang, J., Xing, Y. et al. Near-infrared light-driven multifunctional metal ion (Cu2+)-loaded polydopamine nanomotors for therapeutic angiogenesis in critical limb ischemia. Nano Res. 16, 5108–5120 (2023). https://doi.org/10.1007/s12274-022-5356-2

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  • DOI: https://doi.org/10.1007/s12274-022-5356-2

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