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Carbon-based nanozymes for biomedical applications

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Abstract

Nanozymes are nanomaterials with enzyme-like properties that have attracted significant interest owing to their capability to address the limitations of traditional enzymes such as fragility, high cost, and impossible mass production. Over the past decade, a broad variety of nanomaterials have been found to mimic the enzyme-like activity by engineering the active centers of natural enzymes or developing multivalent elements within nanostructures. Carbon nanomaterials with well-defined electronic and geometric structures have served as favorable surrogates of traditional enzymes by mimicking the highly evolved catalytic center of natural enzymes. In particular, by combining the unique electronic, optical, thermal, and mechanical properties, carbon nanomaterials-based nanozymes can offer a variety of multifunctional platforms for biomedical applications. In this review, we will introduce the enzymatic characteristics and recent advances of carbon nanozymes, and summarize their significant applications in biomedicine.

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Acknowledgements

This work was supported by China Postdoctoral Science Foundation (Nos. 2019T120754 and 2018M633229), Sanming Project of Medicine in Shenzhen (No. SZSM201612031), Natural Science Foundation of Guangdong Province of China (Nos. 2018A030310665 and 2018A0303130295), Shenzhen Science and Technology Innovation Committee (Nos. ZDSYS201707281114196, JCYJ20170306091657539, JCYJ20170413162242627, JCYJ20190806163814395, JCYJ-20170306091452714, and GJHZ20170313172439851), Development and Reform Commission of Shenzhen Municipality (No. S2016005470013), National Key R&D Program of China (No. 2017YFA0205501), and the National Natural Science Foundation of China (Nos. 81722024 and 81571728).

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Authors and Affiliations

  1. Department of Otolaryngology and Institute of Translational Medicine, Shenzhen Second People’s Hospital/the First Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen, 518035, China

    Hui Ding, Bing Hu, Bin Zhang & Guohui Nie

  2. Experimental Center of Advanced Materials, School of Materials Science and Engineering, Beijing Institute of Technology, Beijing, 100081, China

    Minmin Liang

  3. SZU-NUS Collaborative Innovation Center for Optoelectronic Science and Technology, and Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Optoelectronic Engineering, Shenzhen University, Shenzhen, 518060, China

    Han Zhang

  4. Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China

    Xiyun Yan

Authors
  1. Hui Ding
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  2. Bing Hu
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  3. Bin Zhang
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  4. Han Zhang
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  5. Xiyun Yan
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  6. Guohui Nie
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  7. Minmin Liang
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Corresponding authors

Correspondence to Xiyun Yan, Guohui Nie or Minmin Liang.

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Ding, H., Hu, B., Zhang, B. et al. Carbon-based nanozymes for biomedical applications. Nano Res. 14, 570–583 (2021). https://doi.org/10.1007/s12274-020-3053-9

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  • DOI: https://doi.org/10.1007/s12274-020-3053-9

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