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A chemophotothermal and targeting multifunctional nanoprobe with a tumor-diagnosing ability

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Abstract

The development of multifunctional nanoparticles for diagnosis and therapy of cancer has been a focus of research in recent years. Owing to excellent properties of chemophotothermal therapy and tumor targeting accompanied by magnetic resonance (MR) or computed tomography (CT) imaging, mesoporous silica has been widely applied to tumor diagnosing carriers. However, previous research focused more on chemotherapy combined with photothermal therapeutic strategies but ignored intuitive assessment of tumors. In this work, we report a novel nanoprobe consisting of hyaluronic-acid–modified Gold Nanorods@mSiO2@Mn@DOX (GNR@MMH@DOX) nanoparticles, which realize multifunctional integration of therapeutics and imaging. Au nanorods (GNRs) were synthesized without a seed precursor by a water bath method, then sequentially modified with mesoporous silica, doped with Mn2+, and loaded with doxorubicin in a solution. In vitro and in vivo assays verified their great biocompatibility, good stability, and attractive specificity of targeting to receptor CD44, which is overexpressed on cancer cells. In addition, GNR@MMH nanoparticles proved to be a more distinguishable CT/MR imaging contrast compared to commercial contrast agents. The article demonstrates promising composition for CT/MR imaging and photothermal therapy of tumors, giving new insights into the diagnosis and therapy of different kinds of malignant tumors.

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Acknowledgements

The work is supported by Shanghai Science and Technology Development Funds (Nos. 17XD1421900, 14411968100 and 17XD1424200) and Seed Fund of Renji Hospital of Shanghai Jiao Tong University School of Medicine (No. RJZZ16-010).

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  1. Niannian Li, Jiejun Cheng and Ying Zhang contributed equally to this work.

Authors and Affiliations

  1. School of Materials Science and Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China

    Niannian Li, Ying Zhang, Jie Wang & Dannong He

  2. Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China

    Jiejun Cheng

  3. Shanghai University of Medicine & Health Sciences, 279 Zhou Zhu highway, Shanghai, 201318, China

    Gang Huang

  4. National Engineering Research Center for Nanotechnology, 28 East Jiang Chuan Road, Shanghai, 200241, China

    Jun Zhu & Dannong He

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  1. Niannian Li
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  4. Jie Wang
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  5. Gang Huang
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Correspondence to Gang Huang, Jun Zhu or Dannong He.

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Li, N., Cheng, J., Zhang, Y. et al. A chemophotothermal and targeting multifunctional nanoprobe with a tumor-diagnosing ability. Nano Res. 11, 4333–4347 (2018). https://doi.org/10.1007/s12274-018-2021-0

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  • DOI: https://doi.org/10.1007/s12274-018-2021-0

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