Abstract
Arsenic is a potent chemotherapeutic drug that is applied as a treatment for cancer; it exerts its functions through multiple pathways, including angiogenesis inhibition. As angiogenesis is a critical component of the progression of many diseases, arsenic is a feasible treatment option for patients with other angiogenic diseases, including rheumatoid arthritis and psoriasis, among others. However, arsenic is also a well-known carcinogen, demonstrating a pro-angiogenesis effect. This review will focus on the dual effects of arsenic on neovascularization and the relevant mechanisms underlying these effects, aiming to provide a rational understanding of arsenic treatment. In particular, we expect to provide a comprehensive overview of the current knowledge of the mechanisms by which arsenic influences angiogenesis.
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Acknowledgements
This work is supported by National Natural Science Foundation of China (NSFC 81771749) to Zhiyi Zhang, Chinese Postdoctoral Science Foundation (Grant No. 2019M651309) to Juan Zhang, Heilongjiang Provincial Postdoctoral Science Foundation (Grant No. LBH-Z18226) to Juan Zhang, and Scientific Research Innovation Foundation of the First Affiliated Hospital of Harbin Medical University (Grant No. 2019B18) to Juan Zhang.
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Zhang, J., Zhang, Y., Wang, W. et al. Potential molecular mechanisms underlying the effect of arsenic on angiogenesis. Arch. Pharm. Res. 42, 962–976 (2019). https://doi.org/10.1007/s12272-019-01190-5
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DOI: https://doi.org/10.1007/s12272-019-01190-5