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In vivo imaging for neurovascular disease research

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Abstract

Connections between various cell types in the brain enable cognitive function. The neurovascular unit is a structure composed of different cell types that regulate neurovascular coupling, blood–brain barrier permeability, and other interactions with peripheral systems. The relationship among the components of the neurovascular unit is complex and difficult to study without the use of in vivo neurovascular disease imaging. In this review, we introduce principles and examples of various in vivo optical imaging techniques including laser Doppler flowmetry, laser speckle contrast imaging, intrinsic optical signal imaging, optical coherence tomography, and two-photon microscopy. Furthermore, we introduce recent advances of in vivo imaging and future directions for promoting neurovascular disease research.

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Acknowledgements

A special thanks to Ms. Heeyon Jeong who helped us to increase the quality of Fig. 1 and supplementary Fig. 1. This research was supported by the Brain Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (2016M3C7A1913844).

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  1. Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Yuseong-gu, Daejeon, 34141, Republic of Korea

    Jin-Hui Yoon & Yong Jeong

  2. KI for Health Science and Technology, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea

    Jin-Hui Yoon & Yong Jeong

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  1. Jin-Hui Yoon
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Yoon, JH., Jeong, Y. In vivo imaging for neurovascular disease research. Arch. Pharm. Res. 42, 263–273 (2019). https://doi.org/10.1007/s12272-019-01128-x

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