Abstract
An extensive phytochemical investigation on the roots of Glycyrrhiza uralensis led to the isolation of two new minor chalcone acetylglycosides, i.e., 6″-O-acetylisoliquiritin (1) and 6″-O-acetylneoisoliquiritin (2), including 16 kinds of known constituents (3–18) of flavonoids, chalcones and triterpene saponins. The chemical structures of 1 and 2 were established by spectroscopic analyses of them, particularly by the aid of two-dimensional NMR experiments, COSY, DEPT, HSQC and HMBC. Some isolated components except 1 and 2 exhibited significant inhibitory effects on the proliferation of cultured tumor cell lines, such as A549, SK-OV-3, A-498, and HCD15, in vitro.
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Acknowledgments
This research was supported by the basic research Project (KK-1403-C0) of KRICT and also by a Grant of the Technology Innovation Program (10038744) of Korea Evaluation Institute of Industrial Technology (KEIT) funded by Ministry of Trade, Industry & Energy, Republic of Korea.
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Ji Eun Lee and Ji Young Lee contributed equally to this work.
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Lee, J.E., Lee, J.Y., Kim, J. et al. Two minor chalcone acetylglycosides from the roots extract of Glycyrrhiza uralensis . Arch. Pharm. Res. 38, 1299–1303 (2015). https://doi.org/10.1007/s12272-014-0526-y
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DOI: https://doi.org/10.1007/s12272-014-0526-y