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Effect of excipients on dissolution enhancement of aceclofenac solid dispersions studied using response surface methodology: a technical note

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Abstract

The aim of present study was to enhance the dissolution rate of poorly water-soluble drug aceclofenac by solid dispersion technique using corn starch, dicalcium phosphate, lactose, and microcrystalline cellulose as carriers. Solid dispersions were prepared by solvent wetting method using 32 full factorial design for each of the carrier. The prepared solid dispersions were evaluated for differential scanning calorimetry, X-ray diffraction, scanning electron microscopy, Fourier-transform infrared spectroscopy (FTIR), and angle of repose. In vitro dissolution studies were carried out in phosphate buffer (pH 7.5) and 0.1 N HCl (pH 1.2). The results of solid state characterization bring to view that in solid dispersions the crystalline drug gets converted to its amorphous form. FTIR study results indicated the absence of interaction between aceclofenac and carriers. For prepared solid dispersions, angle of repose was found to be in the range of 26.19° to 35.29°, which indicates good flowability. Enhanced drug dissolution was obtained with carrier in order lactose > corn starch > microcrystalline cellulose > dicalcium phosphate. Hence, these carriers could be used to enhance the dissolution rate of poorly water-soluble drug.

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Acknowledgments

The authors are thankful to management of Meerut Institute of Engineering and Technology (UP, India) for providing the necessary facilities. Authors are also thankful to Mr. Jaya Gopal Meher, Research fellow, CSIR-CDRI for helping us to improve the language of the manuscript.

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Authors and Affiliations

  1. Department of Pharmaceutical Technology, Meerut Institute of Engineering and Technology, Delhi-Roorkee Highway, NH-58, Baghpat Crossing, Meerut, 250005, UP, India

    Shobhit Kumar & Satish Kumar Gupta

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  1. Shobhit Kumar
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  2. Satish Kumar Gupta
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Correspondence to Shobhit Kumar.

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Kumar, S., Gupta, S.K. Effect of excipients on dissolution enhancement of aceclofenac solid dispersions studied using response surface methodology: a technical note. Arch. Pharm. Res. 37, 340–351 (2014). https://doi.org/10.1007/s12272-013-0146-y

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  • DOI: https://doi.org/10.1007/s12272-013-0146-y

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