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Multifunctional Role of Polyvinylpyrrolidone in Pharmaceutical Formulations

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Abstract

Polyvinylpyrrolidone (PVP), a non-ionic polymer, has been employed in multifarious fields such as paper, fibers and textiles, ceramics, and pharmaceutics due to its superior properties. Especially in pharmacy, the properties of inertness, non-toxicity, and biocompatibility make it a versatile excipient for both conventional formulations and novel controlled or targeted delivery systems, serving as a binder, coating agent, suspending agent, pore-former, solubilizer, stabilizer, etc. PVP with different molecular weights (MWs) and concentrations is used in a variety of formulations for different purposes. In this review, PVP-related researches mainly in recent 10 years were collected, and its main pharmaceutical applications were summarized as follows: (i) improving the bioavailability and stability of drugs, (ii) improving the physicomechanical properties of preparations, (iii) adjusting the release rate of drugs, and (iv) prolonging the in vivo circulation time of liposomes. Most of these applications could be explained by the viscosity, solubility, hydrophilicity, and hydrogen bond–forming ability of PVP, and the specific action mechanisms for each application were also tried to figure out. The effect of PVP on bioavailability improvement establishes it as a promising polymer in the emerging controlled or targeted formulations, attracting growing interest on it. Therefore, given its irreplaceability and tremendous opportunities for future developments, this review aims to provide an informative reference about current roles of PVP in pharmacy for interested readers.

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Acknowledgments

This work was sponsored by the Natural Science Foundation of Shanghai (18ZR1439800, 18ZR1436600), Three-year Action Plan for the Development of Traditional Chinese Medicine of Shanghai Municipal Health Planning Commission (ZY(2018-2020)-CCCX-2001-03), and the Clinical Research Fund of Shanghai Municipal Health Commission (201940296).

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  1. College of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, People’s Republic of China

    Yu Luo, Lan Shen & Xiao Lin

  2. Engineering Research Center of Modern Preparation Technology of TCM of Ministry of Education, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, People’s Republic of China

    Yu Luo, Yanlong Hong & Fei Wu

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Luo, Y., Hong, Y., Shen, L. et al. Multifunctional Role of Polyvinylpyrrolidone in Pharmaceutical Formulations. AAPS PharmSciTech 22, 34 (2021). https://doi.org/10.1208/s12249-020-01909-4

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