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Induction of secretory leukocyte protease inhibitor (SLPI) in estradiol valerate (EV) induced polycystic ovary

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Abstract

The excessive administration of estradiol valerate induces polycystic ovary syndrome by formation of follicular cysts. Secretory leukocyte protease inhibitor (SLPI) promotes wound healing by decreasing the excessive inflammatory response, stimulating keratinocyte proliferation and increasing collagen deposition through the inhibition of protease activity. In this study, SLPI expression was high in the ovarian stroma, corpus luteum, unilaminar primary follicle, multilaminar primary follicle and granulose layer of the antral follicle in polycystic ovary (PCO) compared to the normal ovary. SLPI was expressed strongly in the theca around the cyst in PCO compared to the mature follicle in the normal ovary. The levels of SLPI mRNA and protein expression were higher in PCO than in the normal ovary, and the level of MMP-2 expression was lower in PCO. These results showed that the formation of a cyst was initiated from a multilaminar primary follicle and SLPI expression was increased depending on the morphological changes in the follicle and ovarian stroma. Therefore, an increase in SLPI may be related to the suppression of tissue disruption, and act as a protease inhibitor in PCO, suggesting that SLPI increases independently of the estrogen concentration in pathological tissues.

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Authors and Affiliations

  1. Department of Oral Histology & Developmental Biology, School of Dentistry, Chosun University, Gwangju, 501-759, Korea

    Jin-Ju Park, Baik-Dong Choi, Soon-Jeong Jeong, Guanlin Wang & Moon-Jin Jeong

  2. College of Veterinary Medicine, Animal Medical Institute, Chonnam National University, Gwangju, 500-757, Korea

    Chun Sik Bae

  3. Department of Dental Hygiene, Eulji University, Seongnam, 461-713, Korea

    Do-Seon Lim

  4. Department of Periodontology, School of Dentistry, Chosun University, Gwangju, 501-759, Korea

    Byung-Ock Kim

  5. Department of Dental Hygiene, Namseoul University, Chunan, 331-707, Korea

    Young-Sik Cho

  6. Department of Dental Hygiene, Division of Health Sciences, Cheongju University, Cheongju, 360-764, Korea

    Sun-Ju Kim

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  1. Jin-Ju Park
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  2. Chun Sik Bae
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Correspondence to Moon-Jin Jeong.

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Park, JJ., Bae, C.S., Choi, BD. et al. Induction of secretory leukocyte protease inhibitor (SLPI) in estradiol valerate (EV) induced polycystic ovary. Arch. Pharm. Res. 34, 1389–1397 (2011). https://doi.org/10.1007/s12272-011-0820-x

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  • DOI: https://doi.org/10.1007/s12272-011-0820-x

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