Abstract
A new (3) and three known germacrane-type sesquiterpenoids were isolated from the chloroform-soluble fraction of the methanolic extract of the bark of Magnolia kobus (Magnoliaceae) through repeated silica gel and Sephadex LH-20 column chromatography. Their chemical structures were elucidated as costunolide (1), parthenolide (2), isobisparthenolidine (3), and bisparthenolidine (4) by spectroscopic analysis. Compounds 1–4 exhibited cytotoxicity against human A549, SK-OV-3, SK-MEL-2, and HCT15 tumor cells.
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Park, H.W., Lee, J.H., Choi, SU. et al. Cytotoxic germacranolide sesquiterpenes from the bark of Magnolia kobus . Arch. Pharm. Res. 33, 71–74 (2010). https://doi.org/10.1007/s12272-010-2227-5
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DOI: https://doi.org/10.1007/s12272-010-2227-5