Abstract
Pure enantiomers are of large interest for several industries. This study was aimed to establish a method for separation of etodolac enantiomers by preferential crystallization after a conglomerate formation of its derivatives. S-(+)-etodolac and R-(−)-etodolac enantiomers were both prepared by classical resolution via crystallization of diastereoisomeric salt with (−)-brucine and (−)-cinchonidine. Enantiomeric purity of etodolac was determined by HPLC method using Chiralcel OD-H column. The pure diastereomeric salt collected from repeated recrystallization was further fractionated by liquid-liquid extraction to pure enantiomers. Etodolac enantiomers were recovered with overall yield more than 20% and the purities were over 99.9%.
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Dung, P.T., Trung, T.Q. & Kim, K.H. Preparative resolution of etodolac enantiomers by preferential crystallization method. Arch. Pharm. Res. 32, 1425–1431 (2009). https://doi.org/10.1007/s12272-009-2012-5
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DOI: https://doi.org/10.1007/s12272-009-2012-5