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In vivo anti-inflammatory effect of a new steroidal saponin, mannioside A, and its derivatives isolated from Dracaena mannii

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Abstract

A new steroidal saponin, mannioside A (1), was isolated from the stem bark of Dracaena mannii, together with the known pennogenin (2), pennogenin-3-O-β-D-glucopyranoside (3) and pennogenin-3-O-α-L-rhamnopyranosyl-(1→2)-[α-L-rhamnopyranosyl-(1→3)]-β-D-glucopyranoside (4). Their structures were determined using 1D-and 2D-NMR spectroscopy and mass spectrometry. Compounds 1 and 3 significantly inhibited carrageenan-induced paw edema in the rat; compound 4 was moderately active whereas 2 showed very weak activity.

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References

  • Agrawal, P. K., Jain, D. C., Gupta, R. K., and Thakur, R. S., Carbon-13 NMR spectroscopy of steroidal sapogenins and steroidal saponins. Phytochemistry, 24, 2479–2496 (1985).

    Article  CAS  Google Scholar 

  • Dong, M., Feng, X.-Z., Wang, B.-Z., Wu, L.-J., and Ikejima, T., Two novel furostanol saponins from the rhizomes of Dioscorea panthaica Prain et Burkill and their cytotoxic activity. Tetrahedron, 57, 501–506 (2001).

    Article  CAS  Google Scholar 

  • Hufford, C. D., Liu, S., and Clark, A. M., Antifungal activity of Trillium grandiflorum constituents. J. Nat. Prod., 51, 94–98 (1988).

    Article  PubMed  CAS  Google Scholar 

  • Lanhers, M. C., Fleurentin, J., Dorfman, P., Motrier, F., and Pelt, J. M., Analgesic, antipyretic and anti-inflammatory properties of Euphorbia hirta. Planta Med., 57, 225–231 (1991).

    Article  PubMed  CAS  Google Scholar 

  • Mahato, S. B., Sahu, N. P., and Ganguly, A. N., Steroidal saponins from Dioscorea foribunda: structures of floribundasaponins A and B. Phytochemistry, 20, 1943–1946 (1981).

    Article  CAS  Google Scholar 

  • McAnuff, A. M., Harding, W. W., Jacobs, H., Omoruyi, E. H., Morrison, E. Y., and Asemota, H. N., Hypoglycemic effect of steroidal saponins Isolated from Jamaican bitter yam, Dioscorea polygonoides. Food Chem. Toxicol., 43, 1667–1672 (2005).

    Article  PubMed  CAS  Google Scholar 

  • Mimaki, Y., Kuroda, M., Takaashi, Y., and Sashida, Y., Steroidal saponins from stems of Dracaena concinna. Phytochemistry, 47, 1351–1356 (1998).

    Article  CAS  Google Scholar 

  • Mimaki, Y., Kuroda, M., Ide, A., Kameyama, A., Yokosuko, A., and Sashida, Y., Steroidal saponins from the aerial parts of Dracaena draco and their cytostatic activity on HL-60 cells. Phytochemistry, 50, 805–813 (1999).

    Article  PubMed  CAS  Google Scholar 

  • Noumi, E., Amvam Z. P. H., and Lontsi, D., Aphrodisiac plants used in Cameroon. Fitoterapia, LXIX,2, 125–134 (1998).

    Google Scholar 

  • Okunji, C. O., Iwu, M. M., and Hostettman, K., Molluscicidal saponins from the fruit pulp of Dracaena mannii. Int. J. Crude Drug Res., 29, 66–70 (1991).

    CAS  Google Scholar 

  • Sautour, M., Miyamoto, T., and Lacaille-Dubois M.-A., Bioactive steroidal saponins from Smilax medica. Planta Med., 72, 667–670 (2004).

    Article  CAS  Google Scholar 

  • Sautour, M., Mitaine-Offer, A.-C., and Lacaille-Dubois, M.-A., The Dioscorea genus: a review of bioactive steroid saponins. J. Nat. Med., 61, 91–101 (2007).

    Article  CAS  Google Scholar 

  • Tapondjou, A. L., Lontsi, D., Sondengam, B. L., Choudhary, M. I., Park, H.-J Choi, J. S., and Lee, K. T., Structure-activity relationship of triterpenoids isolated from Mitragyna stipulosa on cytotoxicity, Arch. Pharm. Res., 25, 270–274 (2002).

    Article  PubMed  CAS  Google Scholar 

  • Tapondjou, A. L., Lontsi, D., Sondengam, B. L., Shaheen, F., Choudhary, M. I., Atta-Ur-Rahman, Heerden, F. R., Park, H.-J., and Lee, K., Saponins from Cussonia bancoensis and their inhibitory effects on nitric oxide production. J. Nat. Prod., 66, 1266–1269 (2003).

    Article  PubMed  CAS  Google Scholar 

  • Tapondjou, A. L., Miyamoto, T., Mirjolet, J-F., Guilbaud, N., and Lacaille-Dubois M-A., Pursaethosides A-E, triterpenes saponins from Entada pursaetha. J. Nat. Prod., 68, 1185–1190 (2005).

    Article  PubMed  CAS  Google Scholar 

  • Teponno, R. B., Tapondjou, A. L., Djoukeng, J. D., Abou-Massour, E., Tabacchi, R., Tane, P., Lontsi, D., and Park, H.-J., Isolation and NMR assignment of a pennogenin glycoside from Dioscorea bulbifera L. var sativa. Nat.I Prod. Sci., 12, 62–66 (2006).

    CAS  Google Scholar 

  • Winter, C. A., Risley, E. A., and Nuss, G. W., Carrageenan-induced edema in hind paw of the rats as an assay for anti-inflammatory drugs. Proc. Soc. Exp. Biol. Med., 3, 544–547 (1962).

    Google Scholar 

  • Zhang, Y., Li, H. Z., Zhang, Y. J., Jacob, R. M., Khan S. I., Li, X. C., and Yang, C. R., Atropurosides A-G, new steroidal saponins from Smilacina atropurpurea, Steroids, 71, 712–719 (2006).

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, University of Dschang, box 183, Dschang, Cameroon

    Leon Azefack Tapondjou, Kemvoufo Beaudelaire Ponou, Remy Bertrand Teponno & Jules Désiré Djoukeng

  2. Department of Animal Biology, Faculty of Science, University of Dschang, box 183, Dschang, Cameroon

    Marius Mbiantcha, Télesphore Benoit Nguelefack & Pierre Watcho

  3. Departament de Ciències Agràries I Del Medi Natural, Escola Superior de Technologia I Ciències Experimentals, Universitat Jaume I, 12071 Castello de la Plana, Jaume, Spain

    Jules Désiré Djoukeng & Aurelio Gomez Cadenas

  4. Department of Pharmaceutical Engineering, Sangji University, Division of Applied Plant Sciences, 660 Woosan-dong, Wonju, 220-702, Korea

    Hee-Juhn Park

Authors
  1. Leon Azefack Tapondjou
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  2. Kemvoufo Beaudelaire Ponou
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  3. Remy Bertrand Teponno
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  4. Marius Mbiantcha
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  5. Jules Désiré Djoukeng
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  6. Télesphore Benoit Nguelefack
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  7. Pierre Watcho
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  8. Aurelio Gomez Cadenas
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  9. Hee-Juhn Park
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Correspondence to Hee-Juhn Park.

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Tapondjou, L.A., Ponou, K.B., Teponno, R.B. et al. In vivo anti-inflammatory effect of a new steroidal saponin, mannioside A, and its derivatives isolated from Dracaena mannii . Arch. Pharm. Res. 31, 653–658 (2008). https://doi.org/10.1007/s12272-001-1208-3

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  • DOI: https://doi.org/10.1007/s12272-001-1208-3

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