Abstract
Solid lipid nanoparticles are promising carriers to improve the bioavailability of poorly water-soluble active pharmaceutical ingredients (APIs). While the available amount of API, especially for newly identified substances in pharmaceutical development is often limited, the dual centrifuge ZentriMix 380 R enables the screening of up to 40 formulations at once in very small batches in closed vials within approximately 10 minutes. Due to the included heating facility and the high stress energy induced by grinding media, lipids with melting temperatures of 73 °C could be processed in this study and monomodal formulations with particle sizes of 133 nm were achieved.
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Literatur
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Steiner, D., Massing, U. & Bunjes, H. Feste Lipidnanopartikel zur Applikation unlöslicher Wirkstoffe. Biospektrum 26, 520–521 (2020). https://doi.org/10.1007/s12268-020-1437-8
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DOI: https://doi.org/10.1007/s12268-020-1437-8