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Herstellung von Nanopartikeln zur Wirkstoffapplikation

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Abstract

A promising way to test poorly soluble active pharmaceutical ingredients (API) in cell culture or in animals is their application as nanoparticles. Dual centrifugation is a new technique to prepare those nanoparticles–nanosuspensions (nanocrystals), liposomes and emulsions. Nanoparticle preparation takes place in small and tightly closed vials, which allows sterile preparations and very small batch sizes. Since up to 40 samples can be processed in parallel, a new dual centrifuge can be used as screening tool.

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Literatur

  1. Massing U, Ingebrigtsen S, Škalko-Basnet N et al. (2017) Dual Centrifugation–A Novel “in-vial” Liposome Processing Technique. In: Catala A (Hrsg) Liposomes. IntechOpen, doi: 10.5772/intechopen.68523

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  2. Hagedorn M, Bögershausen A, Rischer M et al. (2017) Dual centrifugation–a new technique for nanomilling of poorly soluble drugs and formulation screening by an DoE-approach. Int J Pharm 530:79–88

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Authors and Affiliations

  1. Andreas Hettich GmbH & Co. KG Abt. F & E Lifescience Applications, Bismarckallee 7g, D-79098, Freiburg, Germany

    Ulrich Massing & Vittorio Ziroli

  2. Lehrstuhl Für Pharmazeutische Technologie, Institut Für Pharmazeutische Wissenschaften, Universität Freiburg, Freiburg, Germany

    Wolfgang Krämer & Benedikt Deuringer

  3. Losan Pharma Gmbh, Neuenburg, Germany

    Martin Hagedorn

Authors
  1. Ulrich Massing
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  2. Wolfgang Krämer
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  3. Benedikt Deuringer
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  4. Martin Hagedorn
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  5. Vittorio Ziroli
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Corresponding author

Correspondence to Ulrich Massing.

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Massing, U., Krämer, W., Deuringer, B. et al. Herstellung von Nanopartikeln zur Wirkstoffapplikation. Biospektrum 24, 720–721 (2018). https://doi.org/10.1007/s12268-018-0986-6

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  • DOI: https://doi.org/10.1007/s12268-018-0986-6

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