, Volume 24, Issue 2, pp 168–171 | Cite as

Proteomik in kardiovaskulärer Forschung

  • Sophia Doll
  • Michael Wierer
Open Access
Wissenschaft · Special: Proteinanalytik Molekulare Medizin


Cardiovascular diseases are the leading cause of death worldwide. The molecular mechanisms involved in the underlying pathophysiologies of atherosclerosis and heart related disorders are still poorly known. A closer understanding would greatly benefit clinical outcome predictions and treatment options in future. Two recent studies by Matthias Mann and his team, presented in this review, have addressed cardiovascular diseases using high-resolution mass spectrometry-based proteomics.


  1. [1]
    Doll S, Dressen M, Geyer PE, Itzhak DN, Braun C, Doppler SA, Meier F, Deutsch MA, Lahm H, Lange R, Krane M, Mann M (2017) Region and cell-type resolved quantitative proteomic map of the human heart. Nat Commun 8:1469CrossRefPubMedPubMedCentralGoogle Scholar
  2. [2]
    Wierer M, Prestel M, Schiller H, Yan G, Schaab C, Azghandi S, Werner J, Kessler T, Malik R, Murgia M, Aherrahrou Z, Schunkert H, Dichgans M, Mann M (2018) Compartment-resolved proteomic analysis of mouse aorta during atherosclerotic plaque formation reveals osteoclastspecific protein expression. Mol Cell Proteomics 17:321–334CrossRefPubMedGoogle Scholar

Copyright information

© Die Autoren 2018

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits use, duplication, adaption, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

Open access funding provided by Max Planck Society.

Authors and Affiliations

  1. 1.Max-Planck-Institut Für BiochemieMartinsriedGermany

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