Abstract
Cardiovascular diseases are the leading cause of death worldwide. The molecular mechanisms involved in the underlying pathophysiologies of atherosclerosis and heart related disorders are still poorly known. A closer understanding would greatly benefit clinical outcome predictions and treatment options in future. Two recent studies by Matthias Mann and his team, presented in this review, have addressed cardiovascular diseases using high-resolution mass spectrometry-based proteomics.
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Doll S, Dressen M, Geyer PE, Itzhak DN, Braun C, Doppler SA, Meier F, Deutsch MA, Lahm H, Lange R, Krane M, Mann M (2017) Region and cell-type resolved quantitative proteomic map of the human heart. Nat Commun 8:1469
Wierer M, Prestel M, Schiller H, Yan G, Schaab C, Azghandi S, Werner J, Kessler T, Malik R, Murgia M, Aherrahrou Z, Schunkert H, Dichgans M, Mann M (2018) Compartment-resolved proteomic analysis of mouse aorta during atherosclerotic plaque formation reveals osteoclastspecific protein expression. Mol Cell Proteomics 17:321–334
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Sophia Doll Jahrgang 1990. Biologiestudium an der LMU und TU München. Doktorandin am Max-Planck-Institut für Biochemie in Martinsried, 2018 Promotion.
Michael Wierer Jahrgang 1982. Studium der Molekularen Biotechnologie an der TU München. Doktorand am Center for Genomic Regulation, Barcelona, Spanien, 2013 Promotion. Seit 2013 Postdoc am Max-Planck-Institut für Biochemie in Martinsried.
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Doll, S., Wierer, M. Proteomik in kardiovaskulärer Forschung. Biospektrum 24, 168–171 (2018). https://doi.org/10.1007/s12268-018-0899-4
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DOI: https://doi.org/10.1007/s12268-018-0899-4