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Aus zwei mach eins: die Biosynthese der Phenazine

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Abstract

The phenazines are colored secondary metabolites that many bacterial species produce in such large quantities that they are visible to the naked eye. Phenazines are redox-active, enabling them to act as broad-specificity antibiotics and as virulence/survival factors as in the case of the blue pyocyanin produced by the opportunistic pathogen Pseudomonas aeruginosa. Here, we review the current understanding of their biosynthesis from chorismic acid.

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Authors and Affiliations

  1. Struktur und Funktion der Proteine, Helmholtz-Zentrum für Infektionsforschung, Inhoffenstraße 7, D-38124, Braunschweig, Deutschland

    Christina Diederich & Wulf Blankenfeldt

  2. Institut für Organische Chemie, TU Graz, Graz, Österreich

    Mario Leypold & Rolf Breinbauer

  3. Institut für Biochemie, Biotechnologie und Bioinformatik, TU Braunschweig, Braunschweig, Deutschland

    Wulf Blankenfeldt

Authors
  1. Christina Diederich
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  2. Mario Leypold
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  3. Rolf Breinbauer
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  4. Wulf Blankenfeldt
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Corresponding author

Correspondence to Wulf Blankenfeldt.

Additional information

Christina Diederich 2006–2011 Studium der Biochemie und Molekularen Biologie, Universität Bayreuth. Seit 2011 Dissertation bei Prof. Dr. Wulf Blankenfeldt am Helmholtz-Zentrum für Infektionsforschung, Braunschweig.

Rolf Breinbauer 1989–1995 Studium der Technischen Chemie, TU Wien, Österreich. 1998 Promotion, Max-Planck-Institut für Kohlenforschung Mühlheim und Universität Bochum. 1998–1999 Postdoc, Harvard University, Cambridge, MA, USA. 2000–2006 Gruppenleiter am Max-Planck-Institut für Molekulare Physiologie, Dortmund. 2003–2005 Juniorprofessor für Bioorganische Chemie, Universität Dortmund. 2005–2007 Professor für Organische Chemie, Universität Leipzig. Seit 2007 Professor und Vorstand des Instituts für Organische Chemie, TU Graz, Österreich.

Mario Leypold 2006–2011 Chemiestudium, TU Graz, Österreich, dort 2011–2015 Dissertation bei Prof. Dr. Rolf Breinbauer am Institut für Organische Chemie.

Wulf Blankenfeldt 1988–1995 Chemiestudium, TU Braunschweig und National Taiwan Normal University, Republik China. 1999 Promotion, Gesellschaft für Biotechnologische Forschung und TU Braunschweig. 1999–2001 Postdoc, University of St. Andrews, UK. 2002–2010 zunächst Postdoc, dann Gruppenleiter am Max-Planck-Institut für Molekulare Physiologie, Dortmund. 2010–2013 Professor für Biochemie, Universität Bayreuth. Seit 2013 Abteilungsleiter am Helmholtz-Zentrum für Infektionsforschung und Professor für Strukturbiologie der Proteine, TU Braunschweig.

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Diederich, C., Leypold, M., Breinbauer, R. et al. Aus zwei mach eins: die Biosynthese der Phenazine. Biospektrum 22, 137–139 (2016). https://doi.org/10.1007/s12268-016-0666-3

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  • DOI: https://doi.org/10.1007/s12268-016-0666-3

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