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Corynebacterium glutamicum als Produzent von Pyruvat-abgeleiteten Produkten

  • Biotechnologie
  • Maßgeschneiderte Zellfabriken
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Abstract

Pyruvate as a key metabolite of the central metabolism in bacteria is also a precursor for several biotechnologically relevant compounds. Therefore, efforts have been made to tailor the metabolism of the industrially relevant Corynebacterium glutamicum for optimal pyruvate availability and an optimal flux towards pyruvate-derived products. Here we summarize the recent achievements on metabolic engineering of C. glutamicum for production of pyruvate, L-valine, 2-ketoisovalerate and isobutanol.

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Authors and Affiliations

  1. Institut für Bioverfahrenstechnik, Universität Stuttgart, Stuttgart, Deutschland

    Bastian Blombach

  2. Institut für Mikrobiologie und Biotechnologie, Universität Ulm, Albeert-Einstein-Allee 11, D-89081, Ulm, Deutschland

    Bernhard Eikmanns

Authors
  1. Bastian Blombach
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  2. Bernhard Eikmanns
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Correspondence to Bernhard Eikmanns.

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Blombach, B., Eikmanns, B. Corynebacterium glutamicum als Produzent von Pyruvat-abgeleiteten Produkten. Biospektrum 20, 696–699 (2014). https://doi.org/10.1007/s12268-014-0504-4

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  • DOI: https://doi.org/10.1007/s12268-014-0504-4

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